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Home / Biochemicals / Small Molecules

IEM-1921

SKU : BHB21300177

NMDA Receptor Channel Blocker

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Mfr.No.	I-180, I-180_10 mg, I-180_25 mg, I-180_5 mg, I-180_50 mg
Description	IEM-1921 (#I-180) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C12H17N
Synonyms	Synthetic
Background	N-methyl-D-aspartate (NMDA) receptors, a family of L-glutamate receptors, play an important role in the central nervous system. Activation of NMDARs leads to cytosolic free intracellular calcium ((Ca2+)i) increase and for synaptic plasticity1.Abnormal activity of NMDA receptors is associated different neurodegenerative disorders such as Alzheimer's, Huntington's, Parkinson's disease and the etiology of epilepsy1.IEM-1921, also known as 1-phenylcyclohexylamine, is a selective blocker of NMDA receptors. In chronic experiments on Wistar and Krushinskii-Molodkina rats it was found that IEM-1921 (5mg/kg) acts as anticonvulsant. IEM-1921 decreased the duration of convulsions by 82% and prevent neural abnormalities in the brain2-3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-10 uM
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.
Cas Number	2201-24-3
Molecular Weight	175.27
Solubility	Soluble in DMSOUp to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Target	NMDA receptor
Activity	IEM-1921 is a selective NMDA receptor blocker and is a potent anticonvulsant 1-3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-phenylcyclohexan-1-amine

Purity	>99% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Liu, J. et al. (2019) Front. Neurosci.,13, 43. Zaitsev A.V. et al. (2015) J. Neurosci. Res., 93, 454. Vataev S.I. et al. (2020) Neurosci. Behav. Physi., 50, 374. Bolshakov, K.V. et al. (2005) Neuropharm., 49, 144. Bolshakov, K.V. et al. (2003) J. Neurochem., 87, 56. Zaitsev, A.V. et al. (2015) J. Neurosci. Res., 93, 454.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300177-1	I-180_10 mg	10 mg	$147		Add to Cart
BHB21300177-2	I-180_25 mg	25 mg	$292		Add to Cart
BHB21300177-3	I-180_5 mg	5 mg	$92		Add to Cart
BHB21300177-4	I-180_50 mg	50 mg	$466		Add to Cart

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