JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

Isoguvacine hydrochloride

SKU : BHB21300178

An Agonist of GABA(A) Receptors

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	I-185, I-185_100 mg, I-185_25 mg, I-185_250 mg, I-185_50 mg
Description	Isoguvacine hydrochloride (#I-185) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C6H10ClNO2.
Background	Isoguvacine hydrochloride is a specific and potent agonist of GABA(A) receptors with an EC50 value of 3.7-17.3 uM, depending on the subunit composition1. It is a semirigid analogue of trans-4-aminocrotonic acid with limited conformational flexibility and is less potent than GABA1,2.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA action, a major inhibitory neurotransmitter, through the central nervous system, and play an important role in inhibiting cell excitation in the central nervous system. GABA(A) receptors are considered to be a major target of antiseizure drugs3,4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.
Cas Number	68547-97-7
Molecular Weight	163.6
Solubility	Up to 100 mM in water. Centrifuge all product preparations before use (10000 x g, 5 min).
Target	GABA(A) receptors
Source	Synthetic
Activity	Isoguvacine hydrochloride is a specific agonist of the GABA(A) receptors, with EC50 of 3.7-17.3 uM, depending on subunit composition1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1,2,3,6-tetrahydropyridine-4-carboxylic acid;hydrochloride.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Stórustovu, S.I. and Ebert, B. (2006) J. Pharmacol. Exp. Ther. 316, 1351.? White, W.F. and Snodgrass, S.R. (1983) J. Neurochem. 40, 1701. Pomara, N. et al. (2015) Prog. Neuropsychopharmacol. Biol. Psychiatry 56, 35. Iqbal, F. et al. (2011) Bioorg. Med. Chem. Lett. 21, 4252. Stórustovu, S.I. and Ebert, B. (2006) J. Pharmacol. Exp. Ther. 316, 1351.?

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300178-1	I-185_100 mg	100 mg	$117		Add to Cart
BHB21300178-2	I-185_25 mg	25 mg	$66		Add to Cart
BHB21300178-3	I-185_250 mg	250 mg	$235		Add to Cart
BHB21300178-4	I-185_50 mg	50 mg	$85		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.