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Home / Biochemicals / Small Molecules

K252a

SKU : BHB21300190

A Potent Inhibitor of Protein Kinase A, Protein Kinase C, and Protein Kinase G

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Mfr.No.	K-150, K-150_0.1 mg, K-150_0.5 mg, K-150_1 mg, K-150_5 mg, K-150_50 mcg
Description	K252a (#K-150) is a highly pure, natural, and biologically active compound.
Molecular Formula	C27H21N3O5.
Synonyms	Natural
Background	K252a is an alkaloid isolated from Nocardiopisis sp. soil fungi. This ATP analogue is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase (IC50= 1.8 and 1.7 nM respectively). At higher concentrations it is also an efficient inhibitor of serine/threonine protein kinases (IC50 of 10 to 30 nM).1-8It is reported to promote myogenic differentiation in C2 mouse myoblasts5 and has been shown to block the neuronal differentiation of rat pheochromocytoma PC12 cells by inhibition of trk tyrosine kinase activity.9 Paradoxically K252a exerts neurotrophic effects on primary sensory neurons, neuroblastoma cells, PC12 cells, and central neurons.10,11
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-200 nM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	97161-97-2
Molecular Weight	467.5
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Protein kinases
Activity	K252a inhibits a variety of kinases including PKC (IC50 = 25 nM), PKA (IC50 = 18 nM) and PKG (IC50 = 20 nM)1. It also inhibits CaMK (IC50 = 1.8 nM) and MLCK (IC50 = 17 nM). K252a has also been shown to inhibit NGF mediated proliferation through the Trk receptor family2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.Protect from light.

Product Manual	SDS

Reference	Ruegg, U.T. and Burgess G.M. (1989) Trends Pharmacol. Sci. 10, 218. Elliott, L.H. et al. (1990) Biochem. Biophys. Res. Commun. 171, 148. Simpson, D.l. et al. (1991) J. Neurosci. Res. 28, 148. Chin, L.S. et al. (1999) Cancer Invest. 17, 391. Tapley, P. et al. (1992) Oncogene 7, 371. Hashimoto, S. (1998) J. Cell Biol. 107, 1531. Kase, H. et al. (1987) Biochem. Biophys. Res. Commun. 142, 436. Hirayama E. et al. (2001) Biochem. Biophys. Res. Commun. 285, 1237. Borasio, G.D. (1990) Neurosci. Lett. 108, 207. Hashimoto, S. and Hagino A. (1989) Exp. Cell Res. 184, 351. Tischler, A.S. et al. (1991) J. Biol. Chem. 266, 1141. Kase, H. et al. (1987) Biochem. Biophys. Res. Commun. 142, 436. Tapley, P. et al. (1992) Oncogene 7, 371.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300190-1	K-150_0.1 mg	0.1 mg	$92		Add to Cart
BHB21300190-2	K-150_0.5 mg	0.5 mg	$132		Add to Cart
BHB21300190-3	K-150_1 mg	1 mg	$229		Add to Cart
BHB21300190-4	K-150_5 mg	5 mg	$460		Add to Cart
BHB21300190-5	K-150_50 mcg	50 mcg	$76		Add to Cart

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