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Home / Biochemicals / Small Molecules

K252b

SKU : BHB21300191

A Potent Inhibitor of Protein Kinase A, Protein Kinase C, and Protein Kinase G

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Mfr.No.	K-170, K-170_0.45 mg, K-170_50 mcg
Description	K252b (#K-170) is a highly pure, natural, and biologically active compound.
Molecular Formula	C26H19N3O5.
Background	K252b is an alkaloid isolated from Nocardiopsis sp. soil fungi. It is a less potent derivative of K252a,3-5 cell-permeable protein kinase inhibitor.This compound potentiates neurotrophin-3 activity in certain neurons by an unknown mechanism. In other neurons it serves as a control to K252a since it accumulates in the plasma membrane of the neuron.1
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50-500 nM.
Reconstitution	DMSO or DMF. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	99570-78-2
Molecular Weight	453
Solubility	DMSO or DMF. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Protein Kinase A, Protein Kinase C, and Protein Kinase G
Source	Natural
Activity	K252b is a less potent derivative of K252a and inhibits a variety of kinases including PKC (IC50 = 20 nM), PKA (IC50 = 90 nM) and PKG (IC50 = 100 nM)1. It also inhibits MLCK (IC50 = 147 nM) and CaMK (IC50 = 12 nM).
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (9R,10S,12S)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.Protect from light.

Product Manual	SDS

Reference	Yasuzawa T. et al. (1986) J. Antibiotics 39, 1072. Ross, A.H. et al. (1995) J. Neurochem. 65, 2748. Kojima, M. et al. (1995) J. Neurosci Res. 42, 775. Galter, D. and Unsicker, K. (2000) J. Neurosci Res. 61, 295. Taoka, M. et al. (1990) Biochem Biophys Res Commun. 170, 1151. Kase, H. et al. (1987) Biochem. Biopphys. Res. Commun. 142, 436.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300191-1	K-170_0.45 mg	0.45 mg	$519		Add to Cart
BHB21300191-2	K-170_50 mcg	50 mcg	$91		Add to Cart
BHB21300191-3	K-170_50 mcg	5x50 mcg	$355		Add to Cart

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