JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

KC 12291 hydrochloride

SKU : BHB21300187

An Orally Effective Cardioprotective NaV Channel Blocker

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	K-105, K-105_10 mg, K-105_25 mg, K-105_5 mg, K-105_50 mg
Description	KC 12291 hydrochloride (#K-105) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C22H27N3O3SHCl.
Background	The pathophysiological importance of Na+ overload is highlighted by the fact that a variety of drugs reducing Na+ influx proved to be cardioprotective, both at the intact organ and cellular level. In addition, a correlation between the degree of Na+ channel blockade and functional recovery from myocardial infarction is established1.KC 12291 is an orally active atypical voltage-gated sodium channel blocker with cardioprotective properties2-4. It effectively blocks cardiac voltage-gated sodium channels, involving inhibition of the peak Na+ current and thus delays Na+ overload during ischemia by enhancing the inexcitability of the heart4-5.KC 12291 abolishes diastolic contracture in isolated myocytes obtained from guinea-pig atria, with IC50 values of 0.55 and 0.79 uM respectively, and the IC50 for KC 12291 inhibition of the sustained component of Na+ current, INaL, is 9.6 uM6.KC 12291 exerts a potent bradycardic effect in the rat7.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5 - 100 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	181936-98-1
Molecular Weight	449.99
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NaV channels
Source	Synthetic
Activity	Orally active voltage-gated Na+ (NaV) channel blocker1-2 with cardioprotective properties2-4. Inhibits sustained Na+ currents (INaL) with IC50 of 9.6 uM and prevents diastolic contracture in isolated atrial myocytes (IC50 of about 0.7 uM)5.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3,4-Dimethoxy-N-methyl-N-(3-((5-phenyl-1,2,4-thiadiazol-3-yl)oxy)propyl)benzeneethanamine hydrochloride.

Purity	>97%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Takeo, S. et al. (1995) J. Pharmacol. Exp. Ther. 273, 1403. John, G. W. et al. (2004) Cardiovasc. Drug Rev. 22, 17. Ver Donck, L. et al. (1993) Cardiovasc. Res. 27, 349. Hartmann, M. et al. (1998) Naunyn. Schmiedebergs. Arch. Pharmacol. 358, 554. Decking, U. K. et al. (1998) Naunyn. Schmiedebergs. Arch. Pharmacol. 358, 547. Tamareille, S. et al. (2002) J. Cardiovasc. Pharmacol. 40, 346. Létienne, R. et al. (2006) Eur. J. Pharmacol. 530, 243. Decking, U. K. et al. (1998) Naunyn. Schmiedebergs. Arch. Pharmacol. 358, 547. Hartmann, M. et al. (1998) Naunyn. Schmiedebergs. Arch. Pharmacol. 358, 554. Ver Donck, L. et al. (1993) Cardiovasc. Res. 27, 349. John, G.W. et al. (2004) Cardiovasc. Drug Rev. 22, 17. Tamareille, S. et al. (2002) J. Cardiovasc. Pharmacol. 40, 346.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300187-1	K-105_10 mg	10 mg	$167		Add to Cart
BHB21300187-2	K-105_25 mg	25 mg	$297		Add to Cart
BHB21300187-3	K-105_5 mg	5 mg	$129		Add to Cart
BHB21300187-4	K-105_50 mg	50 mg	$561		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.