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Home / Biochemicals / Small Molecules

KN-62

SKU : BHB21300189

An Antagonist of P2X7 Receptors and Inhibitor of CaM kinase II

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Mfr.No.	K-120, K-120_1 mg, K-120_10 mg, K-120_25 mg, K-120_5 mg
Description	KN-62 (#K-120) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C38H35N5O6S2.
Synonyms	Synthetic
Background	KN-62 is a potent and non-competitive antagonist of purinergic P2X7 receptors. In addition, KN-62 acts as a selective cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II (CaM kinase II)1. KN-62 inhibits Bz-ATP-induced currents in HEK-human P2X7 cells and CaM kinase II with IC50 value of 25 nM and 1 uM respectively1.CaM kinase II is very important to synaptogenesis and plasticity during brain development2. The P2X receptors are a family of ion channels that gated by ATP, a ligand that mediates wide critical physiologic functions. P2X7 receptor is responsible for mediating the release of proinflammatory cytokines in inflammatory/immune conditions and pain3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	20 nM - 20 uM.
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	127191-97-3
Molecular Weight	721.85
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 receptor, CaM kinase type II
Activity	KN-62 is a potent non-competitive antagonist of the purinergic P2X7 receptors, shown to inhibit Bz-ATP-induced currents in HEK-hP2X7 cells with IC50 of 25 nM. KN-62 is also a selective, cell permeable inhibitor of Ca2+/calmodulin-dependent kinase type II, with IC50 of approximately 1 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (4-((2S)-2-(isoquinolin-5-ylsulfonyl(methyl)amino)-3-oxo-3-(4-phenylpiperazin-1-yl)propyl)phenyl) isoquinoline-5-sulfonate.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Chessell, I.P. et al. (1998) Br. J. Pharmacol.124, 1314. Min, J.W. et al. (2017) Oncotarget 8, 25513. Bhattacharya, A. et al. (2013) Br. J. Pharmacol. 170, 624. Chessell, I.P. et al. (1998) Br. J. Pharmacol.124, 1314.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300189-1	K-120_1 mg	1 mg	$66		Add to Cart
BHB21300189-2	K-120_10 mg	10 mg	$184		Add to Cart
BHB21300189-3	K-120_25 mg	25 mg	$287		Add to Cart
BHB21300189-4	K-120_5 mg	5 mg	$117		Add to Cart

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