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Home / Biochemicals / Small Molecules

KT5823

SKU : BHB21300194

A Selective PKG Inhibitor

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Alomone Labs

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Mfr.No.	K-250, K-250_0.1 mg, K-250_50 mcg
Description	KT5823 (#K-250) is a highly pure, semi-synthetic, and biologically active compound.
Molecular Formula	C29H25N3O5.
Background	KT5823 is a semi-synthetic derivative of K525a.1 It is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG) (in vitro IC50= 234 nM). KT5823 interferes at the level of the ATP binding site of the catalytic domain of PKG.2,3 The PKG are Ser/Thr protein kinase with broad substrate specificity, and expressed in; brain, smooth muscle cells, platelets, juxtaglomerular kidney cells, and endothelial cells.4,5 KT5823 triggered apoptotic DNA fragmentation in immortalized uterine epithelial cells, suggesting a regulatory role for PKG in the apoptotic process in these cells.6
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	500 nM - 1 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	126643-37-6
Molecular Weight	495
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	L-Type CaV Channels
Source	Semi-synthetic
Activity	KT5823 is a selective and potent inhibitor of PKG (IC50 = 234 nM)1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-di methyl-1-oxo-9,12-epoxy-1H-diindolo(1,2,3-fg:3',2',1'-k l)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, methyl ester.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Kase, H. et al. (1987) B.B.R.C. 142, 436. Hidaka, H. and Kobayashi, R. (1992) Annu. Rev. Pharmacol. Toxicol. 32, 377. Chijiwa, T. et al. (1990) J. Biol. Chem. 265, 5267. Ruth, P. (1999) Pharmacol. Ther. 82, 355. Pfeifer, A. et al. (1998) EMBO J. 17, 3045. Chan, S.L, and Fiscus, R.R. (2003) Mol. Hum. Reprod. 12, 775. Kase, H. et al. (1987) Biochem. Biophys. Res. Commun. 142, 436. Hidaka, H. and Kobayashi, R. (1992) Annu. Rev. Pharmacol. Toxicol. 32, 377.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300194-1	K-250_0.1 mg	0.1 mg	$167		Add to Cart
BHB21300194-2	K-250_50 mcg	0.05 mg	$91		Add to Cart
BHB21300194-3	K-250_50 mcg	5x0.05 mg	$355		Add to Cart

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