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Home / Biochemicals / Small Molecules

Kynurenic acid

SKU : BHB21300188

An Antagonist of Ionotropic Glutamate Receptors and alpha7 nAChR

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Mfr.No.	K-110, K-110_1 g, K-110_10 g, K-110_5 g
Description	Kynurenic acid (#K-110) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H7NO3.
Synonyms	Synthetic
Background	Kynurenic acid (KYNA) is a neuroactive metabolite of the kynurenine pathway of tryptophan degradation. It is a competitive and broad spectrum antagonist of glutamate receptors. Additionally, KYNA antagonizes alpha7 nicotinic acetylcholine receptor and G-protein coupled GPR35 receptor. KYNA is widely used as a pharmacological tool to experimentally eliminate activation of all these receptors in vivo or in vitro1-3.Kynurenine can influence brain function and its levels in the human brain are significantly higher compared to those in other species. Its levels in the brain are normally determined by local neosynthesis from its bioprecursor kynurenine pathway metabolite, since KYNA is not actively transported through the blood-brain barrier.KYNA serves as a substrate for the probenecid-sensitive organic anion transporters OAT1 and OAT3. These proteins are present in brain capillary endothelial cells, thus it is likely that these proteins play an important role in the elimination of KYNA from the brain's extracellular compartment2.KYNA has antioxidant properties and has the ability to eliminate hydroxyl, superoxide anion and other free radicals3.It has been documented that in animal models KYNA may have a positive influence on the number of pathologies in the gastrointestinal tract such as ulcers, colon obstruction and colitis1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 uM - 2 mM.
Reconstitution	Up to 50mM in DMSO or in equimolar NaOH. Mild warming (37°C-42°C) and agitation may be required.
Cas Number	492-27-3
Molecular Weight	189.2
Solubility	Up to 50mM in DMSO or in equimolar NaOH. Mild warming (37°C-42°C) and agitation may be required.
Target	iGluR, alpha7 nAChR
Activity	Kynurenic acid antagonizes ionotropic glutamate receptors with IC50 values of 33 uM (GluK2), 130 uM (GluK1). 100 uM - 3mM antagonizes NMDA response in rat spinal cord.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-oxo-1H-quinoline-2-carboxylic acid.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Turski, M.P. et al. (2013) Int. J. Tryptophan Res. 6, 47. Albuquerque, E.X. and Schwarcz, R. (2013) Biochem. Pharmacol. 85,1027. Schwarcz, R. et al. (2012) Nat Rev Neurosci. 13, 465. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405. Birch, P.J. et al. (1988) Eur. J. Pharmacol. 154, 85.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300188-1	K-110_1 g	1 g	$41		Add to Cart
BHB21300188-2	K-110_10 g	10 g	$202		Add to Cart
BHB21300188-3	K-110_5 g	5 g	$117		Add to Cart

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