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Home / Biochemicals / Small Molecules

L-689,560

SKU : BHB21300208

A Potent and Selective Antagonist of NMDA Receptors

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Alomone Labs

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Mfr.No.	L-225, L-225_10 mg, L-225_25 mg, L-225_5 mg, L-225_50 mg
Description	L-689,560 (#L-225) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H15Cl2N3O3.
Background	L-689,560 is a potent and selective antagonist at the glycine site of N-methyl-D-aspartate (NMDA) receptors. L-689,560 behaves as a full antagonist and competes with glycine for the receptors binding site1. It selectively inhibits (3H)-glycine binding in rat cortex membranes with an IC50 value of 7.4 nM1.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke, and mediate physiological functions such as learning and memory formation and participates in glutamate excitotoxicity2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	139051-78-8
Molecular Weight	380.23
Solubility	Soluble up to 100 mM in DMSO or in ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NMDA receptors
Source	Synthetic
Activity	L-689,560 is a potent and selective antagonist at the glycine site of NMDA receptors, shown to selectively inhibit (3H)-glycine binding in rat cortex membranes with IC50 of 7.4 nM, and to inhibit NMDA-evoked currents in rat cortical neurons with plC50 of 7.461.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2S,4R)-5,7-dichloro-4-(phenylcarbamoylamino)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid.

Purity	>97% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Foster, A.C. et al. (1992) Mol. Pharmacol. 41, 914. Black, S.A. et al. (2014) Front. Cell Dev. Biol. 2, 45. Foster, A.C. et al. (1992) Mol. Pharmacol. 41, 914.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300208-1	L-225_10 mg	10 mg	$254		Add to Cart
BHB21300208-2	L-225_25 mg	25 mg	$561		Add to Cart
BHB21300208-3	L-225_5 mg	5 mg	$168		Add to Cart
BHB21300208-4	L-225_50 mg	50 mg	$985		Add to Cart

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