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Home / Biochemicals / Small Molecules

L-701,324

SKU : BHB21300206

An Antagonist of NMDA Receptors

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Alomone Labs

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Mfr.No.	L-195, L-195_10 mg, L-195_100 mg, L-195_25 mg, L-195_50 mg
Description	L-701,324 (#L-195) is a highly pure, synthetic and biologically active compound.
Molecular Formula	C21H14CINO3
Synonyms	Synthetic
Background	Glutamate is a central excitatory neurotransmitter in the nervous system and his mediating signaling is important for basic neuron-to-neuron signaling and neuronal processes such as learning, memory and pain perception. N-methyl-D-aspartate (NMDA) receptor are the major subtype of glutamate receptors that participate in synaptic transmission. NMDA receptor consists of three different subunits termed GluN1-3. Activation of NMDA receptor carried out via interaction with glycine and glutamate1.L-701,324 (7-chloro-4-hydroxy-3(3-phenoxy) phenylquinoline-2-(H)-on) is an effective NMDA antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine binding site. It was found that L-701,324 when administered orally has an inhibitory effect on spreading depression (SD) initiations and propagation2. Moreover L-701,324 act as anticonvulsant and neuroprotective agent3. Recently it was shown that antidepressant effect of L-701,324 in mice IS mediated by elevating the hippocampal BDNF signaling cascade4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	2 nM - 0.1 uM
Reconstitution	Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing.
Cas Number	142326-59-8
Molecular Weight	363.8
Solubility	Soluble in DMSO. It is recommended to prepare fresh solutions before use. Centrifuge all products before use (10000 x, g 5 min). Avoid multiple freezing and thawing.
Target	NMDA receptor
Activity	L-701,324 is a potent and selective NMDA receptor antagonist that acts at the glycine site1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone

Purity	>97%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Vyklicky, V. et al. (2014) Physiol. Res., 63, S191. Obrenovitch, T. P. et al. (1996) Br. J. Pharmacol., 117, 931. Obrenovitch, T.P. et al. (1997) Naunyn-Schmiedeberg's Arch Pharmacol., 355, 779. Liu, L. et al. (2021) Behav. Brain Res., 399, 113038. Priestley, T. et al. (1996) Neuropharmacol. 35, 1573. Traynelis S. F. et al. (2010) Pharmacol. Rev., 62, 405,

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300206-1	L-195_10 mg	10 mg	$140		Add to Cart
BHB21300206-2	L-195_100 mg	100 mg	$623		Add to Cart
BHB21300206-3	L-195_25 mg	25 mg	$278		Add to Cart
BHB21300206-4	L-195_50 mg	50 mg	$444		Add to Cart

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