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Home / Biochemicals / Small Molecules

LASSBio-1135

SKU : BHB21300205

A Blocker of TRPV1 Channels and Antagonist of TNF-alpha Receptors

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Mfr.No.	L-190, L-190_10 mg, L-190_25 mg, L-190_5 mg, L-190_50 mg
Description	LASSBio-1135 (#L-190) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H14N4.
Synonyms	Synthetic
Background	Transient receptor potential (TRP) channels are important mediators of sensory signaling with significant effect on signal transduction pathways and cellular activity. TRPV is a member of the Vanilloid subfamily of TRP channels1.LASSBio-1135, also known as CHEMBL466188, is a synthetic antagonist of TRPV1 channels and a blocker of TNF-alpha channels. It has an effective concentration of 0.1-100 uM and an IC50 of 588 and 642 nM for TRPV1 and TNF-alpha receptors respectively. LASSbio belongs to a family of imidazo(1,2-a) pyridine derivatives and was found to be an inhibitor of p38 MAPK and COX2 in vivo. However, similar results have not been shown to this day in vitro where LASSbio failed to inhibit p38 MAPK directly and only slightly inhibited COX2. LASSbio is highly effective in completely reducing hyperalgesia induced by capsaicin and inhibits capsaicin evoked currents in a concentration dependent manner. LASSbio also inhibits TNF-alpha production in macrophages stimulated by LPS by reducing p38 MAPK activation through a modulation of an upstream signaling pathway thus making it a possible therapeutic agent for the prevention of neuropathic and other pain2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-100 uM.
Reconstitution	25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	852453-71-5
Molecular Weight	286.3
Solubility	25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	TRPV1 channels, TNF-alpha receptors
Activity	LASSBio-1135 is a TRPV1 channel and a TNF-alpha receptor antagonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-phenyl-2-pyridin-2-ylimidazo(1,2-a)pyridin-3-amine.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Kaneko, Y. et al. (2014) Br. J. Pharmacol. 171, 2474. Lima, C.K. et al. (2014) Plos One 9, e99510. Lima, C.K. et al. (2014) Plos One 9, e99510.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300205-1	L-190_10 mg	10 mg	$235		Add to Cart
BHB21300205-2	L-190_25 mg	25 mg	$527		Add to Cart
BHB21300205-3	L-190_5 mg	5 mg	$151		Add to Cart
BHB21300205-4	L-190_50 mg	50 mg	$943		Add to Cart

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