JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

Linopirdine dihydrochloride

SKU : BHB21300201

A Blocker of KCNQ (KV7) Channels

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	L-156, L-156_10 mg, L-156_25 mg, L-156_5 mg, L-156_50 mg
Description	Linopirdine dihydrochloride (#L-156) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C26H23Cl2N3O.
Background	KCNQ2 (KV7.2) and KCNQ3 (KV7.3) are voltage-gated K+ channel subunits that underlie the neuronal M current1. Linopirdine, a putative cognition enhancing drug, increases acetylcholine (ACh) release in rat brain tissue and improves performance in animal models of learning and memory. In addition to ACh, Linopirdine has been shown to enhance the in vitro release of dopamine and 5-hydroxytryptamine (5-HT), and, to a lesser extent, gamma-aminobutyric acid and glutamate2. The enhanced release of one or more neurotransmitters may account for the activity linopirdine displays in behavioral models of learning and memory3. The mechanism whereby linopirdine enhances acetylcholine release has been proposed to involve inhibition of the M-type K+ current (IM). Linopirdine is selective for IM with an IC50 value of 2.4 uM2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-300 uM.
Reconstitution	100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
Cas Number	113168-57-3
Molecular Weight	464.39
Solubility	100 mM in water. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	KCNQ K+ channels
Source	Synthetic
Activity	Linopirdine blocks KCNQ channels with an IC50 of 2.4 uM for KV7.2/3 heteromers1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one dihydrochloride.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Wickenden, A.D. et al. (2008) Mol. Pharmacol. 73, 977. Schnee, M.E. and Brown, B.S. (1998) J. Pharmacol. Exp. Ther. 286, 709. Aiken, S.P. et al. (1995) Br. J. Pharmacol. 115, 1163. Aiken, S.P. et al. (2012) Br. J. Pharmacol. 115, 1163.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300201-1	L-156_10 mg	10 mg	$229		Add to Cart
BHB21300201-2	L-156_25 mg	25 mg	$537		Add to Cart
BHB21300201-3	L-156_5 mg	5 mg	$132		Add to Cart
BHB21300201-4	L-156_50 mg	50 mg	$1036		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.