JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

m-Chlorophenylbiguanide hydrochloride

SKU : BHB21300216

A Potent and Selective Agonist of 5-HT3 Receptors

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	M-160, M-160_1 g, M-160_500 mg
Description	m-Chlorophenylbiguanide hydrochloride (#M-160) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C8H11Cl2N5.
Synonyms	Synthetic
Background	Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.m-Chlorophenylbiguanide hydrochloride (mCPG) is a prototypical, potent and selective 5-HT3 receptor agonist. In a study conducted in N1E-115 neuroblastoma cells mCPG exhibited inward rectification and reversed currents similar to those induced by 5-HT binding to the 5-HT3 receptor. The rate of receptor desensitization is similar to that of 5-HT binding but the peak current amplitude provoked by the agonist was found to be only 20% at saturating concentration2. Interestingly, mCPG seems to facilitate noradrenaline release in mouse brain cortex cell. When mouse brain slices were incubated with H-noradrenaline, electrical field stimulation was facilitated by mCPG and this effect was blocked by the alpha2 adrenergic receptor antagonist, Rauwolscine3. mCPG binds and activates recombinant alpha9/alpha10 acetylcholine receptors in Xenopus oocytes (although 5-HT does not) thus producing inwards currents that are 3.1±0.7% of the maximum effect obtained by ACh binding4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-20 uM.
Reconstitution	100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	########
Molecular Weight	248.11
Solubility	100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3 channels
Activity	m-Chlorophenylbiguanide is an activator/agonist of 5-HT3 channels1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(3-chlorophenyl)-1-(diaminomethylidene)guanidine;hydrochloride.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hannon, J. and Hoyer, D. (2008) Behav. Brain Res. 195, 198. Sepulveda, M.I. et al. (1991) Br. J. Pharmacol. 104, 536. Schlicker, E. et al. (1994) Naunyn Schmiedebergs Arch. Pharmacol. 349, 20. Rothlin, C.V. et al. (2003) Mol. Pharmacol. 63, 1067. Kilpatrick, G.J. et al. (1990) Eur. J. Pharmacol. 182, 193.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300216-1	M-160_1 g	1 g	$151		Add to Cart
BHB21300216-2	M-160_500 mg	500 mg	$85		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.