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Home / Biochemicals / Small Molecules

M8-B hydrochloride

SKU : BHB21300222

A Potent and Selective Blocker of TRPM8 Channel

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Alomone Labs

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Mfr.No.	M-220, M-220_10 mg, M-220_100 mg, M-220_25 mg, M-220_5 mg, M-220_50 mg
Description	M8-B hydrochloride (#M-220) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C22H25ClN2O3S.
Background	M8-B hydrochloride is a potent and selective antagonist of the transient receptor potential melastatin-8 (TRPM8) channel1. It inhibits rat and human TRPM8 channels by cold, by icilin and by menthol and demonstrates IC50 values of 7.8 nM, 26.9 nM, and 64.3 nM, respectively. The compound shows little or no effect on other TRP channels1.TRPM8 is a Ca2+-permeable channel, a member of the 'long' or melastatin (M) group of TRP channels and is activated by temperatures range of 8-28°C or by cooling compounds. The TRPM8 gene is up-regulated in prostate cancer and other malignancies. The channel is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons2,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 10 uM.
Reconstitution	Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Cas Number	883976-12-3
Molecular Weight	432.96
Solubility	Up to 100 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Target	TRPM8 channel
Source	Synthetic
Activity	M8-B hydrochloride is a potent and selective blocker of TRPM8 channel, inhibiting rat and human TRPM8 activation by cold, by icilin and by menthol with IC50 values of 7.8 nM, 26.9 nM and 64.3 nM, respectively, whilst having little or no effect on other TRP channels (IC50 > 20 uM)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-(2-aminoethyl)-N-((3-methoxy-4 phenylmethoxyphenyl) methyl)thiophene-2 carboxamide;hydrochloride.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Almeida, M.C. et al. (2012) J. Neurosci. 32, 2086. Tsumura, M. et al. (2013) PLoS ONE 8, e82233. Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737. Almeida, M.C. et al. (2012) J. Neurosci. 32, 2086.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300222-1	M-220_10 mg	10 mg	$117		Add to Cart
BHB21300222-2	M-220_100 mg	100 mg	$758		Add to Cart
BHB21300222-3	M-220_25 mg	25 mg	$263		Add to Cart
BHB21300222-4	M-220_5 mg	5 mg	$85		Add to Cart
BHB21300222-5	M-220_50 mg	50 mg	$476		Add to Cart

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