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Home / Biochemicals / Small Molecules

MCI-225

SKU : BHB21300220

A Potent Antagonist of 5-HT3 Channels and a Selective Noradrenaline Reuptake Inhibitor

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Alomone Labs

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Mfr.No.	M-190, M-190_10 mg, M-190_25 mg, M-190_5 mg, M-190_50 mg
Description	MCI-225 (#M-190) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H17FN4S.
Synonyms	Synthetic
Background	MCI-225 is a psychoactive compound, a thienopyrimidine analogue that acts as a selective noradrenaline (NA) reuptake inhibitor with 5-HT3 channel blocking action. The compound demonstrates antidepressant-like activity with primary activity in the central nervous system.Several studies have shown that MCI-225 exhibits improvement in amnesia in scopolamine treated rats and in basal forebrain lesion rats. Acute administration of MCI-225 inhibits the rise of threshold induced by footshock stress1.It has been suggested that MCI-225 may affect attention, learning and memory2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 1 uM.
Reconstitution	30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	135991-48-9
Molecular Weight	328.4
Solubility	30 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3A receptor, NET transporter
Activity	MCI-225 shows high affinity for the 5-HT3 receptor, Ki less than 100 nmol/L1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno(2,3-d)pyrimidine.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Eguchi, J . et al. (1994) Pharmacol. Biochem. Behav. 48, 345. Wu, Y.L. et al. (2000) Jpn. J. Pharmacol. 83, 31. Eguchi, J. et al. (2001) Pharmacol. Biochem. Behav. 68, 677.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300220-1	M-190_10 mg	10 mg	$254		Add to Cart
BHB21300220-2	M-190_25 mg	25 mg	$569		Add to Cart
BHB21300220-3	M-190_5 mg	5 mg	$151		Add to Cart
BHB21300220-4	M-190_50 mg	50 mg	$1019		Add to Cart

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