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Home / Biochemicals / Small Molecules

MPX-004

SKU : BHB21300227

A Potent and Selective Antagonist of GluN2A-containing NMDA Receptors

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Mfr.No.	M-280, M-280_10 mg, M-280_25 mg, M-280_5 mg, M-280_50 mg
Description	MPX-004 (#M-280) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H15ClFN5O3S2.
Background	MPX-004 is a synthetic compound that acts as a potent and selective GluN2A-containing NMDA receptor antagonist with an IC50 value of 79 nM in HEK cells1.MPX-004 is a pyrazine-containing antagonist with optimal halogen substituents on the phenylsulfonamide aryl ring. It is used as a pharmacological tool for studying the physiology of NMDA receptors containing the GluN2A subunit1.NMDA receptors are heterotetramers composed by 2 GluN1 obligatory subunits and 2 GluN2 (A-D) or GluN3 (A-B) regulatory subunits. GluN2A is the most abundant subunit in the mammalian CNS. Physiological and genetic evidence show that GluN2A-containing receptors are involved in autism, schizophrenia, childhood epilepsy and neurodevelopmental disorders such as Rett Syndrome1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	1688684-07-2
Molecular Weight	455.91
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	GluN2A-containing NMDA receptors
Source	Synthetic
Activity	A novel pyrazine-containing NMDA receptor antagonist, highly selective for NR2A-containing receptors (IC50 = 79 nM in HEK cells) over NR2B and NR2D1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (5-(((3-chloro-4-fluoropheyl)sulfonamido)methyl)-N-((2-methylthiazol-5-yl)methyl)pyrazine-2-carboxamide).

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Volkmann, R.A. et al. (2016) PLoS ONE 11, e0148129. Cercato, M.C. et al. (2017) Front. Behav. Neurosci. 10, 242. Volkmann, R.A. et al. (2016) PLoS ONE 11, e0148129.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300227-1	M-280_10 mg	10 mg	$202		Add to Cart
BHB21300227-2	M-280_25 mg	25 mg	$406		Add to Cart
BHB21300227-3	M-280_5 mg	5 mg	$117		Add to Cart
BHB21300227-4	M-280_50 mg	50 mg	$649		Add to Cart

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