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Home / Biochemicals / Small Molecules

NMDA

SKU : BHB21300231

An NMDA Receptor Agonist

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Mfr.No.	N-170, N-170_1 g, N-170_100 mg, N-170_250 mg, N-170_5 g, N-170_50 mg, N-170_500 mg
Description	NMDA (#N-170) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C5H9NO4.
Background	NMDA is the prototypic NMDA receptor agonist. An amino acid that, as a D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors1.NMDA is a water-soluble synthetic substance that is not normally found in biological tissues. It was first synthesized in the 1960s. NMDA is an excitotoxin in high quantities (it kills nerve cells by over-exciting them)2.NMDA activates NMDA receptors by binding to NR2 subunits, leading to the opening of a non-specific cation channel, which can allow the passage of Ca2+ and Na+ ions into the cell and K+ ions out of the cell3.NMDA was evaluated for the inhibition of (3H)MK-801 binding at N-methyl-D-aspartate glutamate receptor and IC50 with an IC50 of 6.86 uM1. Cortical cultures of rat brain neurons have an estimated EC50 value of 6.8 uM4. The EC50 found for NR2 subunit expressed in Xenopus oocytes was 21.7 uM3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	6.5-500 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity
Cas Number	6384-92-5
Molecular Weight	147.1
Solubility	Water. Centrifuge all product preparations before use (10000 x g for 5 min).
Target	NMDA receptors
Source	Synthetic
Activity	Prototypic NMDA receptor agonist. An amino acid that, as a D-isomer, is the defining agonist for the NMDA receptor subtype of glutamate receptors1. NMDA is a water-soluble synthetic substance that is not normally found in biological tissues2. EC50 ranges between 6.5-25.0 uM, depending on the tissue applied on1,3,4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: N-Methyl-D-aspartic acid.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	"N-Methylaspartate compound summary", USA national center for biotechnology information. 24 June 2005.(http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=22880&loc=ec) Flint B.M. et al. (1991) J. Neurosci. 11, 147. Dingledine, R. et al. (1999) Pharmacol. Rev. 51, 7. Blevins, T. et al. (1995) Neurosci. lett. 200, 214.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300231-1	N-170_1 g	1 g	$614		Add to Cart
BHB21300231-2	N-170_100 mg	100 mg	$91		Add to Cart
BHB21300231-3	N-170_250 mg	250 mg	$204		Add to Cart
BHB21300231-4	N-170_5 g	5 mcg	$2578		Add to Cart
BHB21300231-5	N-170_50 mg	50 mg	$55		Add to Cart
BHB21300231-6	N-170_500 mg	500 mg	$354		Add to Cart

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