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Home / Biochemicals / Small Molecules

NS-1619

SKU : BHB21300229

Selective and Potent Enhancer of KCa1.1 Channels and an Inhibitor of SERCA Pumps

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Alomone Labs

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Mfr.No.	N-105, N-105_10 mg, N-105_25 mg, N-105_5 mg
Description	NS-1619 (#N-105) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C15H8F6N2O2.
Background	The large conductance voltage- and Ca2+-activated K+ (BK) channels, also known as BKCa, KCa1.1, Slo, or MaxiK, play an important role in modulating nerve and muscle cell contractility and excitability1-3. BK channels are activated by both depolarizing voltages and by an increase in intracellular free Ca2+, thus coupling the membrane potential to intracellular signaling.NS-1619 is a potent and selective KCa1.1 channel modulator (enhancer)4. It has the potential to modulate cell excitability in neurons and smooth muscle5-7. The effect of relaxation of NS-1619 on the BK channel in smooth muscle cells has an EC50 of 10-30 uM. It is also dose-dependent, resulting in a shift of the activation curve by up to -50 mV towards negative membrane potentials, but fully reversible8.NS-1619 also modulates intracellular Ca2+ by inhibiting SERCA pumps9.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.
Cas Number	153587-01-0
Molecular Weight	362.2
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCa1.1 K+ channels, SERCA pumps
Source	Synthetic
Activity	NS-1619 is a potent and selective KCa1.1 (BK, slo, Large conductance Ca2+-activated K+) channel modulator (enhancer)1. NS-1619 was effective in eliciting and enhancing KCa1.1 channels in smooth muscle as well as in neurons with maximal effects at concentrations around 30 uM1,2. NS-1619 was used in vivo by intracarotid infusion and significantly enhanced blood tumor barrier permeability in the brain tumor area but not in normal brain tissue3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1,3-Dihydro-1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-2H-benzimidazol-2-one.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Andersson K.E. et al. (2004) Physiol. Rev. 84, 935. Heppner, T.J. et al. (1997) Am. J. Physiol. 273, C110. Salkoff, L. et al. (2006) Nat. Rev. Neurosci. 7, 921. Olesen S.P. et al. (1994) Eur. J. Pharmacol. 251, 53. Holland M. et al. (1996) Br. J. Pharmacol. 117, 119. Macmillan S. et al. (1995) Br. J. Pharmacol. 116, 1656. Yamamura H. et al. (2001) Br. J. Pharmacol. 132, 828. Han X. et al. (2008) Biochem. Biophys. Res. Commun. 375, 205. Wrzosek, A. (2014) Cell Calcium 56, 14. Edwards, G. et al. (1994) Br. J. Pharmacol. 113, 1538. Sellers, A.G. and Ashford, L.M.J. (1994) Br. J. Pharmacol. 113, 659. Ningaraj, N.S. et al. (2002) J. Pharmacol. Exp. Ther. 301, 838.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300229-1	N-105_10 mg	10 mg	$129		Add to Cart
BHB21300229-2	N-105_25 mg	25 mg	$261		Add to Cart
BHB21300229-3	N-105_5 mg	5 mg	$91		Add to Cart

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