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Home / Biochemicals / Small Molecules

NS-3623

SKU : BHB21300236

An Opener of KV11.1 (hERG) Channels

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Alomone Labs

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Mfr.No.	N-190, N-190_10 mg, N-190_25 mg, N-190_5 mg, N-190_50 mg
Description	NS-3623 (#N-190) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C15H10BrF3N6O.
Background	The hERG (KV11.1) potassium channel underlies the rapid delayed rectifier current, IKr, which is a major determinant of cardiac repolarization1. IKr strongly modulates action potential duration (APD) and the QT interval at the cellular and organ levels, respectively. Loss of function mutations in hERG results in altered channel gating or impaired intracellular trafficking and reduced cell surface expression. These molecular defects give rise to a congenital form of the long-QT Syndrome type 2 (LQT2) and its associated arrhythmia, torsade de pointes (TdP)2. Recent studies have focused on the use of hERG channel agonists, such as NS-3623, as potential drug candidates for the treatment of cardiac arrhythmic disorders 3. The molecular mechanism of action NS-3623 is to primarily activate the native HERG channels underlying the IKr of the cardiomyocytes with an EC50 value of 10.5 uM4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-200 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	343630-41-1
Molecular Weight	427.18
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	hERG K+ channels
Source	Synthetic
Activity	NS-3623 is an opener of KV11.1 channels with an EC50 of 10.5 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-(4-bromo-2-(1H-tetrazol-5-yl)phenyl)-N -(3-trifluoromethyl-phenyl)urea.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Sanguinetti, M.C. et al. (1995) Cell 81, 299. Akar, F.G. (2010) J. Cardiovasc. Electrophysiol. 21, 930. Hansen, R.S. et al. (2006) Mol. Pharmacol. 70, 1319. Hansen, R.S. et al. (2006) Mol. Pharmacol 69, 266. Hansen, R.S. et al. (2006) Mol. Pharmacol. 70, 1319.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300236-1	N-190_10 mg	10 mg	$273		Add to Cart
BHB21300236-2	N-190_25 mg	25 mg	$611		Add to Cart
BHB21300236-3	N-190_5 mg	5 mg	$188		Add to Cart
BHB21300236-4	N-190_50 mg	50 mg	$1141		Add to Cart

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