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Home / Biochemicals / Small Molecules

NS-6180

SKU : BHB21300243

A Potent Blocker of KCa3.1 Channel

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Alomone Labs

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Mfr.No.	N-230, N-230_10 mg, N-230_25 mg, N-230_5 mg, N-230_50 mg
Description	NS-6180 (#N-230) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H12F3NOS.
Background	The benzothiazinone NS-6180 is a potent and selective KCa3.1 channel blocker1.The Ca2+-activated K+ channel, KCa3.1, plays a major role in the controlled expression of essential genes orchestrating proliferation, migration and cytokine production by participating in the regulation of calcium entry. A highly regulated and sustained increase in cytosolic Ca2+ is critical in these processes thus, the KCa3.1 channel is a potential target for therapy of immune disease1.Inhibition of KCa3.1 channel by NS-6180 demonstrates IC50 value of 14 nM in human, 9 nM in rat and 15 nM in mouse. NS6180 also has the ability to inhibit KCa1.1, KV1.3 and KV11.1 channels with IC50s above 10 uM2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 1 uM.
Reconstitution	100mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	353262-04-1
Molecular Weight	323.3
Solubility	100mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCa3.1 channels
Source	Synthetic
Activity	NS-6180 blocks SK4 channels with IC50 of 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-((3-(Trifluoromethyl)phenyl)methyl)-2H-1,4-benzothiazin-3(4H)-one.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Strøbæk, D. et al. (2013) Br. J. Pharmacol. 168, 432. Koshy, S. et al. (2013) PLoS One. 8, e76740. Strøbæk, D. et al. (2013) Br. J. Pharmacol. 168, 432.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300243-1	N-230_10 mg	10 mg	$117		Add to Cart
BHB21300243-2	N-230_25 mg	25 mg	$262		Add to Cart
BHB21300243-3	N-230_5 mg	5 mg	$85		Add to Cart
BHB21300243-4	N-230_50 mg	50 mg	$468		Add to Cart

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