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Home / Biochemicals / Small Molecules

NS8593

SKU : BHB21300238

A Blocker of KCa2 and TRPM7 Channels

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Alomone Labs

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Mfr.No.	N-196, N-196_10 mg, N-196_25 mg, N-196_5 mg, N-196_50 mg
Description	NS8593 (#N-196) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H17N3.
Background	NS8593 inhibits the gating modulation of all SK, small conductance Ca2+-activated K+ channels (KCa2.1, KCa2.2, KCa2.3) and blocks SK3 channels with an IC50 of 104 nM1,2. It does so by shifting the apparent Ca2+-dependence to higher Ca2+ concentrations2. NS8593 has no effect on other KCa channels1. NS8593 was also found to block TRPM7 currents with an IC50 value of 1.6 uM.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM -10 uM.
Reconstitution	100mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	875755-39-8
Molecular Weight	263.3
Solubility	100mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	SK K+ channels, TRPM7
Source	Synthetic
Activity	NS8593 is KCa2 (SK) channel blocker, with no activity towards KCa3.1 channels, with IC50~100 nM1,2. It also blocks TRPM7 channels3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-((1R)-1,2,3,4-tetrahydronaphthalen-1-yl)-1H-benzimidazol-2-amine.

Purity	>98.5%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Strobaek, D. et al. (2006) Mol. Pharmacol. 70, 1771. Jenkins, D.P. et al. (2011) Mol. Pharmacol. 79, 899. Chubanov, V. et al. (2012) Br. J. Pharmacol. 166, 1357. Jenkins, D.P. et al. (2011) Mol. Pharmacol. 79, 899. Strobaek, D. et al. (2006) Mol. Pharmacol. 70, 1771. Chubanov, V. et al. (2012) Br. J. Pharmacol. 166, 1357.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300238-1	N-196_10 mg	10 mg	$151		Add to Cart
BHB21300238-2	N-196_25 mg	25 mg	$355		Add to Cart
BHB21300238-3	N-196_5 mg	5 mg	$117		Add to Cart
BHB21300238-4	N-196_50 mg	50 mg	$636		Add to Cart

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