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Home / Biochemicals / Small Molecules

Okadaic Acid (ammonium salt)

SKU : BHB21300260

A Potent Inhibitor of Protein Phosphatase 1 and Protein Phosphatase 2

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Mfr.No.	O-800, O-800_0.1 mg, O-800_10 mcg, O-800_25 mcg
Description	Okadaic Acid (ammonium salt) (#O-800) is a highly pure, natural, and biologically active compound.
Molecular Formula	C44H71O13N.
Synonyms	Natural
Background	Okadaic acid is a polyether compound isolated from the black sponge Halichondria okadai. It was previously demonstrated as a non-TPA-type tumor promoter and then as a cell-permeable, potent and specific inhibitor of serine/threonine protein phosphatases 1 and 2A. In higher concentrations Okadaic acid induced apoptosis (IC50 = 0.5 uM).1-4Okadaic acid down-regulates the TNF receptor, induces the release of Ca2+ from intracellular stores in ECV304 endothelial cells and inhibits GH4 cell proliferation in a concentration-dependent manner (IC50 = 5 nM).5,6
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM-1 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	155716-06-6
Molecular Weight	822.04
Solubility	DMSO, ethanol, acetone, or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Protein Phosphatase 1, Protein Phosphatase 2
Activity	Okadaic Acid is a potent inhibitor of PP1 and PP2A1. At higher concentrations, it also promotes apoptosis2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2R)-3-((2S,6R,8S,11R)-2-((E,2R)-4- ((2S,2'R,4R,4aS,6R,8aR)-4-hydroxy-2-((1S,3S)-1-hydroxy-3-((2S,3R,6S)- 3-methyl-1,7-dioxaspiro(5.5)undecan-2-yl)butyl)-3- methylidenespiro(4a,7,8,8a-tetrahydro-4H-pyrano(3,2-b)pyran-6,5'- oxolane)-2'-yl)but-3-en-2-yl)-11-hydroxy-4-methyl-1,7- dioxaspiro(5.5)undec-4-en-8-yl)-2-hydroxy-2-methylpropanoic acid.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.Protect from light.

Product Manual	SDS

Reference	Murakumi, Y et al. (1982) Bull. Jpn. Soc. Sci. Fish. 48, 69. Suganuma, M. et al. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 1768. Cohen, P. et al. (1990) Trends Biochem Sci. 15, 1837. Haystead, T.A. et al. (1989) Nature 337, 78081. Higuchi, M. and Aggarwal, B.B. (1993) J. Biol. Chem. 268, 5624. Van Dolah, F.M. and Ramsdell, J.S. (1992) J. Cell Physiol. 152, 190. Bialojan, C. and Takai, A. (1988) Biochem. J. 256, 283. Meikrantz, W. et al. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 3754.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300260-1	O-800_0.1 mg	0.1 mg	$223		Add to Cart
BHB21300260-2	O-800_10 mcg	10 mcg	$75		Add to Cart
BHB21300260-3	O-800_25 mcg	25 mcg	$91		Add to Cart
BHB21300260-4	O-800_25 mcg	5x25 mcg	$355		Add to Cart

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