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Home / Biochemicals / Small Molecules

Olomoucine

SKU : BHB21300257

A Cyclin-Dependent Kinase (CDK) Inhibitor

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Mfr.No.	O-300, O-300_1 mg, O-300_5 mg
Description	Olomoucine (#O-300) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C15H18N6O.
Background	Olomoucine is a cell-permeable purine protein kinase inhibitor, found to be highly specific for the cell-cycle regulating p34cdc2/cyclin B, p33cdk2/cyclin A and p33cdk2/cyclin E kinases, the brain p33cdk5/p35 kinase and the ERK1/2 MAP- kinase (IC50=7-25 uM).1 Olomoucine behaves as a competitive inhibitor for ATP and as a non-competitive inhibitor for histone H1 binding in CDKs kinases.1-5Olomoucine induces a dose-dependent inhibition of proliferation rate and the cell cycle progression in many human cancer cells in culture (EC50 = 40-90 uM). Olomoucine, at 1-100 uM, slowdown or arrest KB 3-1 cells in G1/S and G2/M phase and decreased the DNA synthesis of rat brain cortex.6-11Olomoucine also induces apoptosis in maturing cerebellar granule neurons,11 NGF induced neuronal differentiation of PC12 cells in vitro12 and in NE cells in vivo.13
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	20-200 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Cas Number	101622-51-9
Molecular Weight	298.35
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Cyclin-Dependent Kinase (CDK)
Source	Synthetic
Activity	Olomoucine selectively inhibits cdc2/cyclin B (IC50 = 7 uM), cdk2/cyclin A (IC50 = 7 uM), cdk2/cyclin E (IC50 = 7 uM), cdk/p35 kinase (IC50 = 3 uM) and ERK1/MAP kinase at higher concentrations (IC50 = 25 uM)1. It also prevents NGF-mediated survival of neuronal cells2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 6-(Benzylamino)-2-(2-hydroxyethylamino)-9-methylpurine.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to two weeks at 4°C or six months at -20°C.

Product Manual	SDS

Reference	Vesely, J. et al. (1994) Eur. J. Biochem. 224, 771. Glab, N. et al. (1994) FEBS Lett. 353, 207. Abraham, R.T. (1995) Biol. Cell 83, 105. Schutte, B. et al. (1997) Exp. Cell Res. 236, 4. Meijer, L. et al. (1997) Eur. J. Biochem. 243, 527. Flament, S. (2000) Zygote 8, 3. Rossi, L.A. et al. (1998) Exp. Cell. Res. 245, 8. Yakisich, J.S. et al. (1998) Biochem. Biophys. Res. Commun. 243, 674. Wesierska-Gadek, J. et al. (2004) Pol. J. Pharmacol. 56, 635. Dobashi, Y. et al. (2000) J. Biol. Chem. 275, 12572. Iseki, H. et al. (1997) Surgery 122, 187. Monaco, E.A. et al. (2004) Biochem. Pharmacol. 67, 1947. Ohnuma, S. et al. (2001) Curr. Opin. Neurobiol. 11, 66. Veseley, J. et al. (1994) Eur. J. Biochem. 224, 771. Monaco, E.A. et al. (2004) Biochem. Pharmacol. 67, 1947.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300257-1	O-300_1 mg	1 mg	$75		Add to Cart
BHB21300257-2	O-300_5 mg	5 mg	$129		Add to Cart
BHB21300257-3	O-300_1 mg	5x1 mg	$282		Add to Cart

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