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Home / Biochemicals / Small Molecules

Oroxylin A

SKU : BHB21300256

An Antagonist of GABA(A) Receptors

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Mfr.No.	O-160, O-160_10 mg, O-160_100 mg, O-160_25 mg, O-160_5 mg, O-160_50 mg
Description	Oroxylin A (#O-160) is a highly pure, natural, and biologically active compound.
Molecular Formula	C16H12O5.
Synonyms	Natural
Background	Oroxylin A, also called 6-Methoxybaicalein, is an antagonist at the benzodiazepine site of the GABA(A) receptors.Oroxylin A is an active O-methylated flavone compound that was originally isolated from the medicinal plant Scutellaria baicalensis. Oroxylin A was shown to have multiple functions, including anti-inflammatory, anti-cancer and anti-thrombotic activities. In addition, it has dopamine reuptake inhibitor activity and an inhibitory effect on nuclear factor-kappaB activation. The compound was used to treat pulmonary infection in Korea, China, and Japan1,2.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA action, a major inhibitory neurotransmitter, through the central nervous system. The GABAA receptor is considered to be a major target of antiseizure drugs3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity.
Cas Number	0480-11-5
Molecular Weight	284.26
Solubility	Up to 50 mM in DMSO. Centrifuge all products before reconstitution (10000 x g 5 min).
Target	GABA(A) receptors
Activity	A flavonoid antagonist at the benzodiazepine site of the GABAA receptors. Inhibits (3H)Flunitrazepam binding to rat cerebral cortical membranes (IC50 = 1.09 uM), and selectively abolishes the anxiolytic, myorelaxant and motor incoordination, but not the sedative and anticonvulsant effects elicited by diazepam in mice1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one.

Purity	>98% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted product for storage.

Product Manual	SDS

Reference	Lee, J.Y. and Park, W. (2016) Exp. Ther. Med. 12, 151. Kwon, B.E. et al. (2016) PLoS One 11, 5. Pomara, N. et al. (2015) Prog. Neuropsychopharmacol. Biol. Psychiatry 56, 35. Huen, M.S. et al. (2003) Biochem. Pharmacol. 66, 125.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300256-1	O-160_10 mg	10 mg	$85		Add to Cart
BHB21300256-2	O-160_100 mg	100 mg	$459		Add to Cart
BHB21300256-3	O-160_25 mg	25 mg	$180		Add to Cart
BHB21300256-4	O-160_5 mg	5 mg	$66		Add to Cart
BHB21300256-5	O-160_50 mg	50 mg	$287		Add to Cart

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