JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

Parthenolide

SKU : BHB21300271

A Nuclear Factor-kappaB (NF-kappaB) Pathway Inhibitor

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	P-250, P-250_25 mg, P-250_5 mg, P-250_50 mg
Description	Parthenolide (#P-250) is a highly pure, natural, and biologically active compound.
Molecular Formula	C15H20O3.
Background	Parthenolide is a sesquiterpene lactone found in Mexican-Indian medicinal plants such as Tanacetum parthenium. It has been widely used in indigenous medical practices for the treatment of migraine, inflammation and tumors.1-4 Parthenolide inhibits IkB kinase (IKK) and IKKbeta (the upstream activators of the Nuclear Factor-kB (NF-kB) pathway), thus inhibiting Interleukin 1- and tumor necrosis factor a (TNFalpha) without affecting the activation of p38 and c-Jun N-terminal kinase.5,6In breast adenocarcinoma and pancreatic tumor cell lines which constitutively express active NF-kappaB, parthenolide inhibits NF-kappaB DNA binding and increases sensitivity to chemotherapeutic agents. The sensitivity of these tumor cells to parthenolide is due to the low expression level of the multifunctional detoxification enzyme glutathione S-transferase p caused by inhibition of NF-kappaB activity.7,10
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-50 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes). The lyophilizate may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. Soluble in DMSO. Prepare a concentrated stock solution by dissolving the lyophilized peptide in DMSO first (e.g., at a concentration between 100-1000x of the final working concentration). Once the peptide is completely dissolved in DMSO, slowly dilute the solution into the working buffer (or water) to the desired final working concentration. Centrifuge all product preparations before use. It is recommended to keep the DMSO concentration as low as possible. For cell assays, a final concentration of 0.1%0.5% DMSO (v/v) is considered safe. For other experiments, a 5% DMSO (v/v) concentration is recommended
Cas Number	20554-84-1
Molecular Weight	248.3
Solubility	DMSO, ethanol, methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Source	Natural
Activity	Parthenolide is a sesquiterpene lactone and inhibits IkappaB kinase (IKK) and IKKbeta (the upstream activators of the Nuclear Factor-kappaB (NF-kappaB) pathway)1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (1aR,7aS,10aS)- 1a,5-dimethyl-8-methylene- 2,3,6,7,7a,8,10a,10b- octahydrooxireno(9,10)cyclodeca (1,2-b)furan-9(1aH)-one.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or six months at -20°C.

Product Manual	SDS

Reference	Johnson, E.S. et al. (1985) Br. Med. J. 291, 569. Biggs, M.J. et al. (1982) Lancet 2, 776. Hall, I.H. et al. (1979) J. Pharmacol. Sci. 68, 537. Douros, J. and Suffness, M. (1978) Cancer Chemother. Pharmacol. 1, 91. Lee, K.H. et al. (1977) Science 196, 533. Bork, P.M. et al. (1997) FEBS Lett. 402, 85. Hehner, S.P. et al. (1999) J. Immunol. 163, 5617. Patel, N.M. et al. (2000) Oncogene 19, 4159. Wang, W. et al. (1999) Clin. Cancer Res. 5, 119. Wen, J. et al. (2002) J. Biol. Chem. 277, 38954. Lee, K.H. et al. (1977) Science 196, 533. Bork, P.M. et al. (1997) FEBS Lett. 402, 85.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300271-1	P-250_25 mg	25 mg	$91		Add to Cart
BHB21300271-2	P-250_5 mg	5 mg	$55		Add to Cart
BHB21300271-3	P-250_50 mg	50 mg	$107		Add to Cart
BHB21300271-4	P-250_5 mg	5x5 mg	$206		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.