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Home / Biochemicals / Small Molecules

Paxilline

SKU : BHB21300289

A Mycotoxin Blocker of KCa1.1 (BK) Channels and SERCA Pumps

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Alomone Labs

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Mfr.No.	P-450, P-450_0.45 mg, P-450_1 mg, P-450_10 mg, P-450_25 mg, P-450_5 mg
Description	Paxilline (#P-450) is a highly pure, natural, and biologically active compound.
Molecular Formula	C27H33NO4.
Background	Paxilline is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Penitrem A and Verruculogen.2Paxilline enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine.1 Paxilline was shown to inhibit the peptidyle toxin resistant combination a+b4 channels (for more background see 3) expressed in CHO cells.4 It was shown to be as potent as Iberiotoxin in action potential broadening in hippocampus and amygdala.4,5Paxilline also inhibits intracellular Ca2+-ATPases (SERCA) with IC50s between 5 and 10 uM6.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-100 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	57186-25-1
Molecular Weight	435.6
Solubility	DMSO or acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCa K+ channels, SERCA pump
Source	Natural
Activity	Paxilline is a selective blocker of high-conductance Ca2+-activated (Maxi-K) K+ channels.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,1 4a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b ,12c-dimethyl-2H-pyrano(2'',3'':5',6')benz(1',2':6,7)in deno(1,2-b)indol-3(4bH)-one.

Purity	>98% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Selala, M.I. et al. (1991) J. Nat. Prod. 54, 207. Knaus, H.G. et al. (1994) Biochemistry 33, 5819. Modulator Issue No. 17.pdf Hu, H. et al. (2001) J. Neurosci. 21, 9585. Faber, E.S. and Sah, P. (2002) J. Neurosci. 22, 1618. Bilmen, J.G. et al. (2002) Arch. Biochem. Biophys. 406, 55.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300289-1	P-450_0.45 mg	0.45 mg	$47		Add to Cart
BHB21300289-2	P-450_1 mg	1 mg	$57		Add to Cart
BHB21300289-3	P-450_10 mg	10 mg	$325		Add to Cart
BHB21300289-4	P-450_25 mg	25 mg	$725		Add to Cart
BHB21300289-5	P-450_5 mg	5 mg	$170		Add to Cart

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