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Home / Biochemicals / Small Molecules

PD-161989 2-hydroxyethanesulfonate

SKU : BHB21300278

An Antagonist of AMPA Receptors

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Alomone Labs

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Mfr.No.	P-285, P-285_10 mg, P-285_25 mg, P-285_5 mg, P-285_50 mg
Description	PD-161989 2-hydroxyethanesulfonate (#P-285) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H22N4O8S.
Synonyms	Synthetic
Background	Glutamate is the major excitatory neurotransmitter in the central nervous system (CNS). AMPA receptors are ionotropic glutamate channels, play a key role in the development and function of the nervous system and are essential in memory and learning1.PD-161989 2-hydroxyethanesulfonate is a synthetic, potent and selective antagonist of AMPA glutamate receptors. It has an effective concentration of 0.1-100 uM.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	1262770-05-7
Molecular Weight	430.43
Solubility	Up to 20 mM in H2O or DMSO (slowly, clear yellow solution). Centrifuge all products before reconstitution (10000 x g 5 min).
Target	AMPA receptors
Activity	PD-161989 2-hydroxyethanesulfonate is an AMPA receptor antagonist.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-hydroxyethanesulfonic acid;6-methyl-7-nitro-5-(pyrrolidin-1-ylmethyl)-1,4-dihydroquinoxaline-2,3-dione.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.

Product Manual	SDS

Reference	Armstrong, N. et al. (1998) Nature 395, 913.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300278-1	P-285_10 mg	10 mg	$202		Add to Cart
BHB21300278-2	P-285_25 mg	25 mg	$451		Add to Cart
BHB21300278-3	P-285_5 mg	5 mg	$117		Add to Cart
BHB21300278-4	P-285_50 mg	50 mg	$808		Add to Cart

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