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Home / Biochemicals / Small Molecules

Penitrem A

SKU : BHB21300291

A Blocker of KCa1.1 (BK) Channels

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Mfr.No.	P-650, P-650_0.65 mg
Description	Penitrem A (#P-650) is a highly pure, natural, and biologically active compound.
Molecular Formula	C37H44ClNO6.
Synonyms	Natural
Background	Penitrem A is widely used to probe KCa1.1 channels in smooth muscle preparations, where it induces prolongation of the depolarization plateau potential.1 Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Verruculogen (#V-500) and Paxilline (#P-450).2 Penitrem A (400 mg mycelium/kg) increased the spontaneous release of endogenous glutamate, GABA (gamma-aminobutyric acid), and aspartate by 213%, 455%, and 277%, respectively, from rat cerebrocortical synaptosomes.3
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-100 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	12627-35-9
Molecular Weight	634.2
Solubility	DMSO, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCa1.1 K+ channels
Activity	Penitrem A is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels1. Penitrem A increases the spontaneous release of endogenous GABA (3-aminobutyric acid), and aspartate2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (1S,2R,5S,6S,8R,9S,10R,12S,15R,16S,25R,27S,28R)-21-chloro-15,16,33,33-tetramethyl-24-methylidene-10-prop-1-en-2-yl-7,11,32-trioxa-18--)tritriaconta25,28.022,29.019,30.017,31.06,12.06,8.05,15.02,16zadecacyclo(25.4.2.0a17(31),19,21,29-tetraene-5,9,28-triol

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hollywood, M. A. et al. (2000) Am. J. Physiol. 279, C420. Knaus, H. G. et al. (1994) Biochemistry 33, 5819. Norris, P.J. et al. (1980) J. Neurochem. 34, 33. Hollywood, M. A. et al. (2000) Am. J. Physiol. 279, C420. Norris, P.J. et al. (1980) J. Neurochem. 34, 33.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300291-1	P-650_0.65 mg	0.65 mg	$91		Add to Cart
BHB21300291-2	P-650_0.65 mg	5x0.65 mg	$355		Add to Cart

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