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Home / Biochemicals / Small Molecules

PNU-120596

SKU : BHB21300285

A Potent and Selective Positive Allosteric Modulator of alpha7 nAChR

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Alomone Labs

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Mfr.No.	P-350, P-350_10 mg, P-350_100 mg, P-350_25 mg, P-350_50 mg
Description	PNU-120596 (#P-350) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C13H14ClN3O4.
Background	PNU-120596 is as a potent and selective positive allosteric modulator of alpha7 nicotinic acetylcholine receptors (nAChRs). It potentiates nAChR alpha7 currents in Xenopus oocytes and in SH-EP1 cells with EC50 values of 1.6 uM and 216 nM, respectively1-2. The compound displays neuroprotective characteristics in vivo and has the ability to increase the potency and maximal efficacy of agonists and to prolong the duration of the agonist-evoked macroscopic currents1,2.nAChRs receptors are responsible for mediating the effects of the neurotransmitter acetylcholine (ACh). They play critical roles in the central and peripheral nervous system where they regulate neurotransmitter release, cell excitability, neuronal integration. They are involved in functions such as sleep and arousal patterns, fatigue, hunger, anxiety, and pain processing2,3,4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.3-10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	501925-31-1
Molecular Weight	311.72
Solubility	Soluble to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	alpha7 nAChR
Source	Synthetic
Activity	PNU-120596 is a potent and selective type-II positive allosteric modulator of alpha7 nicotinic acetylcholine receptors, shown to potentiate alpha7 currents in X. Laevis oocytes and in SH-EP1 cells with EC50 values of 1.6 uM and 216 nM, respectively1-2. Neuroprotective in vivo3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methyl-1,2-oxazol-3-yl)urea.

Purity	>98% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Gronlien, J.H. et al. (2007) Mol. Pharmacol. 72, 715. Hurst, R.S. et al. (2005) J. Neurosci. 25, 4396. Kalappa, B.I. et al. (2013) Br. J. Pharmacol. 169, 1862. Lustig, L.R. (2006) Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 288, 424. Gronlien, J.H. et al. (2007) Mol. Pharmacol. 72, 715. Hurst, R.S. et al. (2005) J. Neurosci. 25, 4396. Kalappa, B.I. et al. (2013) Br. J. Pharmacol. 169, 1862.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300285-1	P-350_10 mg	10 mg	$76		Add to Cart
BHB21300285-2	P-350_100 mg	100 mg	$479		Add to Cart
BHB21300285-3	P-350_25 mg	25 mg	$151		Add to Cart
BHB21300285-4	P-350_50 mg	50 mg	$266		Add to Cart

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