JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

PNU 282987

SKU : BHB21300263

Selective Agonist of alpha7 nAChR

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	P-110, P-110_10 mg, P-110_100 mg, P-110_25 mg, P-110_5 mg, P-110_50 mg
Description	PNU 282987 (#P-110) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C14H17ClN2O.
Background	Nicotinic acetylcholine receptors (nAChRs) are members of the Cys-Loop ligand-gated ion channel superfamily, located both in the peripheral and central nervous systems (PNS and CNS, respectively). These receptors, existing as both homopentameric and heteropentameric transmembrane ion channels, are validated therapeutic targets for various CNS pathologies1.PNU 282987 is a selective agonist of alpha7 nAChRs2-3, which are predominantly found in the central nervous system. It enhances alpha7 nAChRs currents with an EC50 of 5.6 uM in Xenopus oocytes4 and has a Ki of 26 nM in rat alpha7 nAChR2. Selective alpha7 nAChR agonists, such as PNU 282987, improve performance in sensory gating, novel object recognition, social recognition, water maze performance, or inhibitory avoidance models of cognitive function4. Given these roles, targeting alpha7 nAChRs has been considered as a viable strategy for a variety of diseases involving cognitive deficits and neurodegeneration5-6.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	EC50 ~ 5 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	123464-89-1
Molecular Weight	264.75
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	alpha7 nAChR
Source	Synthetic
Activity	PNU 282987 is a selective agonist of alpha7 nicotinic acetylcholine receptor (nAChR)1-2, with an EC50 of 5.6 uM in Xenopus oocytes3 and Ki of 26 nM in rat alpha7 nAChR1. Via modulating/enhancing hippocampal GABAergic neurotransmission, PNU 282987 improves auditory gating and enhances hippocampal oscillatory activity and therefore may offer a potential pharmacotherapy in the treatment of schizophrenia1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-(3R)-1-Azabicyclo(2.2.2)oct-3-yl-4-chlorobenzamide.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Kombo, D.C. et al. (2011) Eur. J. Med. Chem. In Press. Hajós, M. et al. (2005) J. Pharmacol. Exp. Ther. 312, 1213. Bodnar, A.L. et al. (2005) J. Med.Chem. 48, 905. Grønlien, J.H. et al. (2007) Mol. Pharmacol. 72, 715. Levin, E.D. et al (2002) Curr. Drug Targets CNS Neurol. Disord. 1, 423. Gotti, C. et al (2006) Curr. Pharm. Des. 12, 407. Hajós, M. et al. (2005) J. Pharmacol. Exp. Ther. 312, 1213. Bodnar, A.L. et al. (2005) J. Med.Chem. 48, 905. Grønlien, J.H. et al. (2007) Mol. Pharmacol. 72, 715.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300263-1	P-110_10 mg	10 mg	$66		Add to Cart
BHB21300263-2	P-110_100 mg	100 mg	$425		Add to Cart
BHB21300263-3	P-110_25 mg	25 mg	$134		Add to Cart
BHB21300263-4	P-110_5 mg	5 mg	$50		Add to Cart
BHB21300263-5	P-110_50 mg	50 mg	$235		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.