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Home / Biochemicals / Small Molecules

Quin-C7

SKU : BHB21300295

An Antagonist of FPR2 Receptor

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Mfr.No.	Q-155, Q-155_10 mg, Q-155_25 mg, Q-155_5 mg, Q-155_50 mg
Description	Quin-C7 (#Q-155) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C25H25N3O4.
Synonyms	Synthetic
Background	Quin-C7 is a synthetic quinazolinone derivative that acts as a nonpeptide antagonist of human formyl peptide receptor like 1 (FPRL1, FPR2)1. Quin-C7 can partially displace ((125)I)Trp-Lys-Tyr-Met-Val-d-Met-NH(2) (WKYMVm) binding to FPRL1 receptor1.The formyl peptide receptors include the FPR1, FPR2, and FPR3. FPR2 is primarily expressed in neutrophils and monocytes where it plays an important role in inflammation and in the immune system1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Cas Number	871100-12-8
Molecular Weight	431.49
Solubility	Soluble up to 100 mM in DMSO. Spin down all products before handling.
Target	FPR2 receptors
Activity	Quin-C7 is a nonpeptide antagonist of N-formyl peptide receptor 2 (FPR2, FPRL1), shown to partially displace (125I)WKYMVm from FPR2 receptors, and inhibit WKYMVm-induced calcium mobilization and chemotaxis at 100uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-butoxy-N-(2-(4-hydroxyphenyl)-4-oxo-1,2-dihydroquinazolin-3-yl)benzamide.

Purity	>96%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C for several months. It is recommended to aliquot stock solutions to avoid repeated thawing and freezing.

Product Manual	SDS

Reference	Zhou, C. et al. (2007) Mol. Pharmacol. 72, 976. Prat, C. et al. (2009) J. Immunol. 183, 6569. Zhou, C. et al. (2007) Mol. Pharmacol. 72, 976.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300295-1	Q-155_10 mg	10 mg	$459		Add to Cart
BHB21300295-2	Q-155_25 mg	25 mg	$917		Add to Cart
BHB21300295-3	Q-155_5 mg	5 mg	$287		Add to Cart
BHB21300295-4	Q-155_50 mg	50 mg	$1360		Add to Cart

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