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Home / Biochemicals / Small Molecules

Ro 8-4304 hydrochloride

SKU : BHB21300306

A Selective Antagonist of NMDA Receptors

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Mfr.No.	R-165, R-165_10 mg, R-165_25 mg, R-165_5 mg, R-165_50 mg
Description	Ro 8-4304 hydrochloride (#R-165) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C21H24ClFN2O3.
Background	Ro 8-4304 hydrochloride is a non-competitive antagonist of NMDA (N-methyl-d-aspartate) receptors. Ro 8-4304 effect is a voltage-independent and demonstrates selectivity to NR2B subtype of the NMDA receptor. The compound exhibits affinity for recombinant NMDA NR2B receptors that is at least 100 fold higher than NR2A receptors1. It has an IC50 value 0.39 mM1. Ro 8-4304 acts in an ifenprodil-like (another selective inhibitor of the NMDA receptor) mechanism. It was shown to be neuroprotective in both in vitro and in vivo models of ischaemia1,2.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. NMDAR plays an important role in a variety of cellular processes and brain functions such as, synaptic plasticity, addiction and stroke.NMDA receptors mediate physiological functions such as learning and memory formation and play a role in glutamate excitotoxicity3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-250 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	195988-65-9
Molecular Weight	406.88
Solubility	Up to 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NMDA receptors
Source	Synthetic
Activity	Ro 8-4304 is a non-competitive, state-dependent, voltage-independent NMDA receptor antagonist, highly selective for NR2B- over NR2A-containing receptors (IC50 = 0.4 uM for NR2B, >100 fold higher for NR2A, in Xenopus oocytes)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-(3-(4-(4-fluorophenyl)-3,6-dihydro-2H-pyridin-1-yl)-2-hydroxypropoxy)benzamide; hydrochloride.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Kew, J.N. et al. (1998) Br. J. Pharmacol. 123, 463. Kew, J.N. et al. (1998) J. Physiol. 512, 17. Black, S.A. et al. (2014) Front. Cell Dev. Biol. 2, 45. Kew, J.N. et al. (1998) Br. J. Pharmacol. 123, 463.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300306-1	R-165_10 mg	10 mg	$168		Add to Cart
BHB21300306-2	R-165_25 mg	25 mg	$373		Add to Cart
BHB21300306-3	R-165_5 mg	5 mg	$117		Add to Cart
BHB21300306-4	R-165_50 mg	50 mg	$672		Add to Cart

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