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Home / Biochemicals / Small Molecules

SB 203580

SKU : BHB21300334

A MAPK Homologue-p38 Inhibitor

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Alomone Labs

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Mfr.No.	S-370, S-370_1 mg, S-370_5 mg
Description	SB 20358 (#S-370) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C21H16FN3OS.
Background	SB203580 is highly selective and cell permeable pyridinyl imidazole that inhibits the activity of MAP kinase homologs - p38 (stress-activated protein kinase II/HOG1) and p54 (stress-activated protein kinase I/c-Jun N-terminal kinase) with IC50 values of 50 and 500 nM for p38/SAPK2a and p38/SAPK2b respectively.1-6 SB203580 also inhibits the phosphorylation and activation of protein kinase B (PKB, also known as Akt) by inhibiting the PKB kinase, phosphoinositide-dependent protein kinase 1 (IC50 3-5 uM).7-9
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-100 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	152121-47-6
Molecular Weight	377.44
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	MAPK Homologue-p38
Source	Synthetic
Activity	SB 203580 is a specific inhibitor for the p38 MAP kinase homologues1-6.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-(5-(4-Fluorophenyl)-2-(4-(methylsulfonyl)phenyl)- 1H-imidazol-4-yl)pyridine.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to two weeks at 4°C or six months at -20°C.Protect from light.

Product Manual	SDS

Reference	Lee, J.C. et al. (1994) Nature 372, 739. Cuenda, A. et al. (1995) FEBS Lett. 364, 229. Whitmarsh, A.J. et al. (1997) Mol. Cell. Biol. 17, 2360. Clerk, A. et al. (1998) FEBS Lett. 426, 93. Hunt, A.E. et al. (1999) J. Biol. Chem. 274, 7591. Ward, S.G. et al. (1997) Biochem. Soc. Trans. 2, 304S. Lali F.V. et al. (2000) J. Biol. Chem. 275, 7395. Martin, M. et al. (2003) Infect. Immun. 71, 2498. Darveau, R.P. et al. (2002) Infect. Immun. 70, 1867. Lee, J.C. et al. (1994) Nature 372, 739. Cuenda, A. et al. (1995) FEBS Lett. 364, 229. Whitmarsh, A.J. et al. (1997) Mol. Cell. Biol. 17, 2360. Clerk, A. et al. (1998) FEBS Lett. 426, 93. Hunt, A.E. et al. (1999) J. Biol. Chem. 274, 7591. Ward, S.G. et al. (1997) Biochem. Soc. Trans. 2, 304S.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300334-1	S-370_1 mg	1 mg	$129		Add to Cart
BHB21300334-2	S-370_5 mg	5 mg	$223		Add to Cart
BHB21300334-3	S-370_1 mg	5x1 mg	$506		Add to Cart

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