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Home / Biochemicals / Small Molecules

SB-366791

SKU : BHB21300324

A Specific and Potent TRPV1 Blocker

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Alomone Labs

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Mfr.No.	S-180, S-180_10 mg, S-180_25 mg, S-180_50 mg
Description	SB-366791 (#S-180) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H14ClNO2.
Background	SB-366791 is a potent and selective TRPV1 channel antagonist1. Novel strategies for the treatment of bone cancer pain have shown that morphine in combination with SB-366791 has potent analgesic effects on bone cancer pain2.TRPV1 (Vanilloid receptor-1) is a member of a distinct subgroup of transient receptor potential (TRP) family. These channels are highly expressed on primary nociceptors. TRPV1 can be activated by several different stimuli such as heat, acid, certain arachidonic acid derivatives and direct phosphorylation via PKC. TRPV1 may serve a central role in inflammatory nociception3.Studies have shown that local intradermal treatment with SB-366791 compound has the ability to reduce thermal hyperalgesia and mechanical allodynia without affecting mechanical hyperalgesia4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	5 nM - 50 uM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	472981-92-3
Molecular Weight	287.7
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	TRPV1 channels
Source	Synthetic
Activity	SB-366791 is a TRPV1 channel antagonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Gunthorpe, M.J. et al. (2004) Neuropharmacology 46, 133. Niiyama, Y. et al. (2009) Br. J. Anaesth. 102, 251. McLeod, R.L. et al. (2006) Cough 2, 10. Uchytilova, E. et al. (2014) Mol. Pain 10, 67. Gunthorpe, M.J. et al. (2004) Neuropharmacology 46, 133.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300324-1	S-180_10 mg	10 mg	$85		Add to Cart
BHB21300324-2	S-180_25 mg	25 mg	$184		Add to Cart
BHB21300324-3	S-180_50 mg	50 mg	$333		Add to Cart

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