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Home / Biochemicals / Small Molecules

SB-705498

SKU : BHB21300321

A Blocker of TRPV1 Channels

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Alomone Labs

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Mfr.No.	S-160, S-160_10 mg, S-160_100 mg, S-160_25 mg, S-160_5 mg, S-160_50 mg
Description	SB-705498 (#S-160) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H16BrF3N4O.
Background	SB-705498 is a specific and potent antagonist for TRPV1. Generally, TRPV1 inhibitors are classified as either both capsaicin and proton blockers, and mainly capsaicin blockers. SB-705498 belongs to the first class2. After experimenting with lesser potent and effective antagonists, the major advantageous modification the compound's developers had introduced into the related TRPV1 archetypal inhibitors was a trifluoromethyl-substituted pyridine ring; it presented SB-705498 with good solubility and oral bioavailability, superior pharmacokinetic properties1-3.SB-705498 was developed as an intranasal medication for the treatment of neuropathic and inflammatory pain. Recent clinical trials checked the effectiveness of the compound in treating rhinitis, alleviating dental pain, and relieving acute migraine headache2,4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 50 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	501951-42-4
Molecular Weight	428.05
Solubility	DMSO 100 mM. Centrifuge all product preparations before use (10000 x g 1 min).
Target	TRPV1 channels
Source	Synthetic
Activity	SB-705498 is a potent orally active TRPV1 blocker1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (R)-1-(2-bromophenyl)-3-(1-(5-(trifluoromethyl)pyridin-2-yl)pyrrolidin-3-yl)ureaN-(2-bromophenyl)-N -(((R)-1-(5-trifluoromethyl-2-pyridyl)pyrrolidin-3-yl))urea.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Kort, M.E. and Kym, P.R. (2012) Prog. Med. Chem. 51, 57. Szallasi, A. et al. (2007) Nat. Rev. Drug Discov. 6, 357. Conway, S.J. (2008) Chem. Soc. Rev. 37, 1530. Holland, C. et al. (2014) Br. J. Clin. Pharmacol. 77, 777. Gunthorpe, M.J. et al. (2007) J. Pharmacol. Exp. Ther. 321, 1183. Kort, M.E. and Kym, P.R. (2012) Prog. Med. Chem. 51, 57. Szallasi, A. et al. (2007) Nat. Rev. Drug Discov. 6, 357. Conway, S.J. (2008) Chem. Soc. Rev. 37, 1530. Holland, C. et al. (2014) Br. J. Clin. Pharmacol. 77, 777.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300321-1	S-160_10 mg	10 mg	$202		Add to Cart
BHB21300321-2	S-160_100 mg	100 mg	$1426		Add to Cart
BHB21300321-3	S-160_25 mg	25 mg	$476		Add to Cart
BHB21300321-4	S-160_5 mg	5 mg	$117		Add to Cart
BHB21300321-5	S-160_50 mg	50 mg	$901		Add to Cart

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