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Home / Biochemicals / Small Molecules

Serotonin hydrochloride

SKU : BHB21300322

Agonist of all 5-HT Receptors and Transporters

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Mfr.No.	S-165, S-165_1 g, S-165_100 mg, S-165_250 mg, S-165_500 mg
Description	Serotonin hydrochloride (#S-165) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H13ClN2O.
Background	Serotonin is the endogenous agonist of 5-HT receptors and the endogenous substrate for the synthesis of a number of molecules, such as melatonin, formyl5hydroxykynurenamine, and 5hydroxyindoleacetic acid.Serotonin (5HT), also known as 5hydroxytryptamine is a monoamine derived from tryptophan. Primarily, serotonin can be found in the gastrointestinal tract, blood platelets, and the central nervous system (CNS)1. Only 2% of serotonin is present in the CNS where it plays an important role in the etiology of many mental disorders. 5-HT also plays an important role in regulating mood and social behavior, appetite, sleep, pain, bone density, tissue regeneration, platelet aggregation, gastrointestinal function, memory and sexual desire and function1,2. In addition, serotonin affects the immune, gastrointestinal and nervous systems in a paracrine, endocrine, and juxtacrine manner2.An extensive use or overdose of serotonergic drugs can lead to a rare life threatening syndrome called serotonin syndrome that includes mental status changes, neuromuscular abnormalities and autonomic hyperactivity3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50 nM - 50 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	153-98-0
Molecular Weight	212.7
Solubility	150 mM in water. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT1, 5-HT2, 5-HT3 receptors
Source	Synthetic
Activity	Serotonin is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Arreola, R. et al. (2015) J. Immunol. Res. 2015, 354957. Lin, S.H. et al. (2014) Clin. Psychopharmacol Neurosci. 12, 196. Gaffney, R.R. et al. (2015) Case. Rep. Gastroenterol. 9, 132. Barnes, N.M. et al. (1999) Neuropharmacology 38, 1083.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300322-1	S-165_1 g	1 g	$235		Add to Cart
BHB21300322-2	S-165_100 mg	100 mg	$50		Add to Cart
BHB21300322-3	S-165_250 mg	250 mg	$110		Add to Cart
BHB21300322-4	S-165_500 mg	500 mg	$195		Add to Cart

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