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Home / Biochemicals / Small Molecules

SKA-31

SKU : BHB21300317

A Potent Activator of KCa3.1 and KCa2 Channels and a Blocker of TRPM7 Channel

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Alomone Labs

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Mfr.No.	S-120, S-120_10 mg, S-120_25 mg, S-120_5 mg, S-120_50 mg
Description	SKA-31 (#S-120) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C11H8N2S.
Background	Ca2+-activated potassium channels (KCa) are a group of 6/7-TM proteins that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance, respectively). The three small-conductance Ca2+-activated K+ channels KCa2.1 (SK1), KCa2.2 (SK2), and KCa2.3 (SK3)1, and the intermediate-conductance KCa3.1 channel (IK1, SK4) play important roles in various physiological functions by modulating Ca2+-signaling cascades and regulating membrane potential, in the CNS and also peripherally1-2.Outside of the nervous system KCa2 channels, especially KCa2.3, are involved in blood pressure regulation3, contractility of urinary bladder smooth muscle and metabolism4. Like KCa2.3, KCa3.1 is further expressed in vascular endothelium and contributes to blood pressure control by initiating the so-called endothelium derived hyperpolarizing factor (EDHF) response, a nitric oxide and prostacyclin independent component of endothelium-dependent relaxation5-9.SKA-31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900, 1900 nM for KCa3.1, KCa2.1, KCa2.3 and KCa2.2 respectively)10. It potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice, by 4-6 and 12 mmHg, respectively10-11.SKA-31 was found to block TRPM7 channels, demonstrating an overlap between pharmacological compounds acting on TRP and KCa channels12.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	40172-65-4
Molecular Weight	200.2
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCa2, KCa3.1, TRPM7 channels
Source	Synthetic
Activity	SKA-31 is an activator of KCa3.1 and KCa2 channels (EC50 values are 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively)1. Potentiates acetylcholine-induced EDHF-type dilations of mouse carotid arteries and lowers blood pressure in normotensive and hypertensive mice1,2. SKA-31 blocks TRPM73.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: Naphtho(1,2-d)thiazol-2-ylamine.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Kohler, M. et al. (1996) Science 273, 1709. Ishii, T.M. et al. (1997) Proc. Natl. Acad. Sci. U.S.A 94, 11651. Taylor, M.S. et al. (2003) Circ. Res. 93, 124. Wulff, H. et al. (2007) Curr. Med. Chem. 14, 1437. Edwards, G. et al. (1998) Nature 396, 269. Eichler, I. et al. (2003) Br. J. Pharmacol. 138, 594. Fleming, I. et al. (2006) Circ. Res. 99, 462. Kohler, R. et al. (2007) Kidney. Int. 72, 145. Si, H. et al. (2006) Circ. Res. 99, 537. Sankaranarayanan, A. et al. (2009) Mol. Pharmacol. 75, 281. Brahler, S. et al. (2009) Circulation 119, 2323. Chubanov, V. et al. (2012) Br. J. Pharmacol. 166, 1357. Sankaranarayanan, A. et al. (2009) Mol. Pharmacol. 75, 281. Brahler, S. et al. (2009) Circulation 119, 2323. Chubanov, V. et al. (2012) Br. J. Pharmacol. 166, 1357.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300317-1	S-120_10 mg	10 mg	$91		Add to Cart
BHB21300317-2	S-120_25 mg	25 mg	$167		Add to Cart
BHB21300317-3	S-120_5 mg	5 mg	$75		Add to Cart
BHB21300317-4	S-120_50 mg	50 mg	$261		Add to Cart

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