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Home / Biochemicals / Small Molecules

SR 48692

SKU : BHB21300332

A Potent and Selective Antagonist of Neurotensin Receptor 1

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Alomone Labs

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Mfr.No.	S-265, S-265_10 mg, S-265_25 mg, S-265_5 mg, S-265_50 mg
Description	SR 48692 (#S-265) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C32H31ClN4O5.
Synonyms	Synthetic
Background	SR 48692 is a potent and selective antagonist of neurotensin receptor 1 (NTR1/NTS1). The compound demonstrates hydrophobic and aromatic features1,2. SR 48692 has been shown to antagonize neurotensin receptor actions in intestinal preparations, thus considered to be a useful tool in studying the physiological role of neurotensin receptor in the digestive tract. in vitro studies show that SR 48692 antagonizes NT-induced dopamine release in guinea pig striatal slices and NT-stimulated Ca2+ mobilization in HT29 cells1. In guinea pig ileum preparations, the compound displays an IC50 value of 33.5 nM1.The two neurotensin receptors, NTR1 and NTR2, belong to the family of G-protein-coupled receptors1,2. The receptors are expressed in the brain and gastrointestinal tract where they play a role in pain transmission and intestinal motility.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1 uM.
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	146362-70-1
Molecular Weight	587.07
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	Neurotensin Receptor 1
Activity	SR 48692 is a potent and selective non-peptide antagonist of NTS1 receptors, shown to inhibit neurotensin-stimulated IP production (Ki = 2.45 nM) and NTR1-mediated calcium mobilization1-3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-((1-(7-chloroquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazole-3-carbonyl)amino)adamantane-2-carboxylic acid.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Labbe-Jullie, C. et al. (1994) J. Pharmacol. Exp. Ther. 271, 267. Labbe-Jullie, C. et al. (1998) J. Biol. Chem. 273, 16351. Thomas, J.B. et al. (2009) Bioorg. Med. Chem. Lett. 19.5, 1438.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300332-1	S-265_10 mg	10 mg	$219		Add to Cart
BHB21300332-2	S-265_25 mg	25 mg	$459		Add to Cart
BHB21300332-3	S-265_5 mg	5 mg	$134		Add to Cart
BHB21300332-4	S-265_50 mg	50 mg	$816		Add to Cart

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