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Home / Biochemicals / Small Molecules

Staurosporine

SKU : BHB21300333

A Potent Inhibitor of Protein Kinase A, Protein Kinase C, and Protein Kinase G

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Mfr.No.	S-350, S-350_0.1 mg, S-350_0.47 mg, S-350_1 mg, S-350_50 mcg
Description	Staurosporine (#S-350) is a highly pure, natural, and biologically active compound.
Molecular Formula	C28H26N4O3.
Synonyms	Natural
Background	Staurosporine is a member of the K252a family of fungal alkaloids produce by Streptomyces staurospores.1,2 It is one of the most potent, cell permeable protein kinase inhibitors, and it is often used to study the involvement of protein kinases in signal transduction pathways (IC50 0.7-20 nM).3-10In pheochromocytoma PC12 cells, neuroblastoma and brain primary culture Staurosporine is a functional neurotropins agonist promoting neurite outgrowth (EC50 = 50 nM).11-12 At concentrations higher then 0.5 mM, Staurosporine generates apoptosis in several different cell types or induces G1 and G2 phase arrest in normal cells.13-16
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 1 uM.
Reconstitution	DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	62996-74-1
Molecular Weight	466
Solubility	DMSO or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	PKA, PKC, PKG
Activity	Staurosporine potently inhibits a variety of kinases including PKC (IC50 = 0.7 nM), PKA (IC50 = 7 nM) and PKG (IC50 = 8.5 nM)1,2. It also inhibits CaMK (IC50 = 20 nM)3 and MLCK (IC50 = 1.3 nM)1,2. In addition, Staurosporine can act as an agonist promoting neurite outgrowth4. At higher concentrations, Staurosporine induces apoptosis5.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (9S-(9a,10b,11b,13a))-2,3,10,11,12,13-Hexahydro-10- meth oxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo (1,2,3- gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-1-one.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to one week at 4°C or three months at -20°C.Protect from light.

Product Manual	SDS

Reference	Ruegg U.T. and Burgess, G.M. (1989) Trends Pharmacol. Sci. 10, 218. Tamaoki, T. et al. (1986) Biochem. Biophys. Res. Commun. 135, 397. Matsumoto, H. et al. (1989) Biochem. Biophys. Res. Commun. 158, 105. Couldwell, W.T. et al. (1994) FEBS Lett. 345, 43. Bruno, S. et al. (1992) Cancer Res. 52, 470. Vitale, M.L. et al. (1992) Neuroscience 51, 463. Hoffman, R. and Newlands, E.S. (1991) Cancer Chemother. Pharmacol. 28, 102. Begemann, M. et al. (1998) Anticancer Res. 18, 3139. Oh, Y.J. et al. (1997) Brain Res. Mol. Brain Res. 51, 133. Hou, S.T. et al. (2000) J. Neurochem. 75, 91. Rasouly, D. et al. (1992) Mol. Pharmacol. 42, 35. Yao, R. et al. (1997) J. Biol. Chem. 272, 18261. Kruman, I. et al. (1998) J. Neurosci. Res. 51, 293. Jacobsen, M.D. et al. (1996) J. Cell Biol. 133, 1041. Posmantur, R. et al. (1997) J. Neurochem. 68, 2328. Chakravarthy, B.R. et al. (1999) J. Neurochem. 72, 933. Tamaoki, T. et al. (1986) Biochem. Biophys. Res. Commun. 135, 397. Matsumoto, H. et al. (1989) Biochem. Biophys. Res. Commun. 158, 105. Yanagihara, N. et al. (1991) J. Neurochem. 56, 294. Rasouly, D. et al. (1992) Mol. Pharmacol. 42, 35. Wang, X. et al. (1996) EMBO J. 15, 1012.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300333-1	S-350_0.1 mg	0.1 mg	$107		Add to Cart
BHB21300333-2	S-350_0.47 mg	0.47 mg	$448		Add to Cart
BHB21300333-3	S-350_1 mg	1 mg	$614		Add to Cart
BHB21300333-4	S-350_50 mcg	50 mcg	$75		Add to Cart
BHB21300333-5	S-350_50 mcg	5x50 mcg	$282		Add to Cart

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