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Home / Biochemicals / Small Molecules

Talipexole dihydrochloride

SKU : BHB21300056

An Antagonist of 5-HT3 Channel, an Agonist of D2 Dopamine Receptor and alpha2-Adrenoceptor

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Mfr.No.	B-140, B-140_10 mg, B-140_25 mg, B-140_5 mg, B-140_50 mg
Description	Talipexole dihydrochloride (#B-140) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H15N3S2HCl.
Synonyms	Synthetic
Background	Talipexole is an azepine derivative, and acts as an agonist of D2 dopamine pre- and postsynaptic receptors, as well as an alpha2-adrenoceptor agonist and 5-HT3 receptor antagonist1.The purpose of Talipexole is to increase dopamine activity in the central nervous system. It inhibits electrically evoked release of dopamine through activation of D2 synaptic autoreceptors located on dopaminergic terminals. It also causes release of acetylcholine and noradrenalin2,3.Talipexole has been established in a number of clinical trials as an anti-Parkinsonian agent. These trials showed significant improvement in motor activity and in other parkinsonian symptoms including akinesia, rigidity, tremor and gait disturbances. There are several side effects caused by this drug such as drowsiness, dizziness, hallucinations, gastrointestinal discomfort, nausea and loss of appetite3.In addition, talipexole is also expected to be beneficial for the treatment of periodic leg movement disorder and restless leg syndrome4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.3-300 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity
Cas Number	36085-73-1
Molecular Weight	282.23
Solubility	100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3, D2 dopamine, alpha2-adrenoceptor receptors
Activity	B-HT 920 is a blocker of 5-HT3 channels1. It is also an agonist of D2 dopamine receptors and alpha2-adrenoceptors.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 6-prop-2-enyl-4,5,7,8-tetrahydro-(1,3)thiazolo(4,5-d)azepin-2-amine;dihydrochloride.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Nishio, H. et al. (1996) Gen. Pharmacol. 27, 779. Clarke, P.B. et al. (1990) Br. J. Pharmacol. 99, 509. Plosker, G.L. and Benfield, P. (1997) CNS Drugs 7, 410. Inoue, Y. et al. (1999) Psychiatry Clin. Neurosci. 53, 283. Nishio, H. et al. (1996) Gen. Pharmacol. 27, 779.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300056-1	B-140_10 mg	10 mg	$151		Add to Cart
BHB21300056-2	B-140_25 mg	25 mg	$254		Add to Cart
BHB21300056-3	B-140_5 mg	5 mg	$117		Add to Cart
BHB21300056-4	B-140_50 mg	50 mg	$451		Add to Cart

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