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Home / Biochemicals / Small Molecules

Tanshinone II-A sodium sulfonate

SKU : BHB21300342

An Opener of KCa1.1 Channel

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Mfr.No.	T-165, T-165_10 mg, T-165_25 mg, T-165_5 mg, T-165_50 mg
Description	Tanshinone II-A sodium sulfonate (#T-165) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C19H17O6SNa.
Synonyms	Synthetic
Background	KCa1.1 channel is a large conductance Calcium-activated potassium channel (BKCa) known to regulate the repolarization of action potential discharge through molecular association with high voltage activated calcium channels.Tanshinone II-A sodium sulfonate (TIIAS) is a water soluble derivative of Tanshinone IIA. Tanshinone IIA is an active constituent of the herb Danshen (Salvia miltiorrhiza) widely used in Chinese traditional medicine for coronary artery disease, hypertension and other cardiovascular diseases due to its properties of arterial dilatation. TIIAS is a synthetic opener of KCa1.1 channels with an effective concentration 10-200 uM. TIIAS increases the total permeability of BKCa in a concentration dependent manner. TIIAS has an EC50 of 111.5 uM at 0.01 uM Ca2+ and an EC50 of 68.5 uM at 0.1 uM Ca2+ 2. Similar to Danshen, TIIAS has beneficial effects on cardiac vasodilatation, reduction of oxidative stress and lipid profile. Interestingly, when used in a rat model of preeclampsia TIIAS reduced oxidative stress, however it did not lead to an improvement in pregnancy outcome criteria such as maternal blood pressure and fetal biometrics3. TIIAS was also found to have analgesic properties in neuropathic pain via inhibition of the spinal astrocytic JNK/MCP-1 pathway and the reduction of IL-1beta and TNF-alpha expression4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-200 uM.
Reconstitution	10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	69659-80-9
Molecular Weight	396.4
Solubility	10 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCa1.1 channel
Activity	Tanshinone II-A sodium sulfonate is a KCa1.1 channel opener1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: sodium;1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho(1,2-g)(1)benzofuran-2-sulfonate.

Purity	>=98%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Rehak, R. et al. (2013) Plos One 8, e61844. Tan, X. et al. (2011) Eur. J. Pharmacol. 656, 27. Morton, J.S. et al. (2015) Am. J. Physiol. 308, R163. Tang, J. et al. (2015) J. Neuroinflammation. 12, 57. Tan, X.Q. et al. (2014) Acta. Pharmacol. Sin. 35, 1359.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300342-1	T-165_10 mg	10 mg	$134		Add to Cart
BHB21300342-2	T-165_25 mg	25 mg	$297		Add to Cart
BHB21300342-3	T-165_5 mg	5 mg	$85		Add to Cart
BHB21300342-4	T-165_50 mg	50 mg	$476		Add to Cart

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