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Home / Biochemicals / Small Molecules

Taurine

SKU : BHB21300337

An Endogenous Partial Agonist of Glycine Receptors and Taurine Transporters

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Mfr.No.	T-130, T-130_10 g, T-130_100 g, T-130_25 g, T-130_5 g
Description	Taurine (#T-130) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C2H7NO3S.
Synonyms	Synthetic
Background	Taurine (2-aminoethanesulfonic acid) is a beta-amino acid, one of the most abundant free amino acids found in vertebrates. Taurine can be present in many tissues including brain, myocardium, and kidney. It plays an important role in several physiological processes including cardiac contraction, antioxidation, blunting of hypertension, bile acid conjugation, maintenance of calcium homeostasis, osmoregulation, and membrane stabilization.Taurine acts as an endogenous partial agonist at the inhibitory glycine receptor (GlyR)1,2.The glycine receptor is a member of the ligand-gated ion channel (LGIC) superfamily. The receptor mediates fast inhibitory neurotransmission in the mammalian spinal cord and parts of the brain3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.05-5 mM.
Reconstitution	>100mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	107-35-7
Molecular Weight	125.15
Solubility	>100mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Glycine receptor, Taurine transporter
Activity	Taurine is a Glycine receptor (GlyR) partial agonist (EC50=1.7 mM)1. It displaces (3H)Strychnine bound to GlyR alpha1 expressing 293 cells membrane fraction (Ki=170 uM)2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-aminoethanesulfonic acid.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Wang, X. et al. (2016) Sci. Rep. 6, 21231. He, YU. et al. (2016) Anticancer Res. 36, 533. Rajendra, S. et al. (1995) EMBO J. 14, 2987. Schmieden, V. et al. (1999) Mol. Pharmacol. 56, 464. Rajendra, S. et al. (1995) EMBO J. 14, 2987.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300337-1	T-130_10 g	10 g	$66		Add to Cart
BHB21300337-2	T-130_100 g	100 g	$117		Add to Cart
BHB21300337-3	T-130_25 g	25 g	$85		Add to Cart
BHB21300337-4	T-130_5 g	5 g	$50		Add to Cart

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