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Home / Biochemicals / Small Molecules

tBuBHQ

SKU : BHB21300349

A Potent Inhibitor of Sarcolasmic Reticulum Ca2+ ATPase

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Mfr.No.	T-220, T-220_1 g, T-220_250 mg, T-220_5 g
Description	tBuBHQ (#T-220) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C14H22O2.
Synonyms	Synthetic
Background	tBuBHQ is a chemically synthesized compound1. It is widely used as a potent selective inhibitor of the sarcoplasmic reticulum Ca2+ ATPase pump (SERCA). The pump transfers Ca2+ from the cell cytosol to the endoplasmic reticulum lumen during muscle relaxation. Inhibition of SERCA by tBuBHQ causes a dose-dependent, sustained, and marked increase of cytoplasmatic Ca2+ and store-operated Ca2+ depletion1. tBuBHQ also causes superoxide anion production independently of Ca2+ secretion2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-10 uM.
Reconstitution	Ethanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	88-58-4
Molecular Weight	222.33
Solubility	Ethanol or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	SERCA
Activity	tBuBHQ is an inhibitor of the endoplasmic reticulum Ca2+-ATPase1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Chemical Name: 2,5-Ditert-butylbenzene-1,4-diol.

Purity	>97%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to one week at 4°C.Protect from light.

Product Manual	SDS

Reference	Ershoff BH. (1969) Proc. Soc. Exp. Biol. Med. 131, 776. Tsukii. K. et al. (1996) Eur. J. Pharmacol. 298, 87. Kass, G. E.N. et al. (1989) J. Biol. Chem. 264, 15192.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300349-1	T-220_1 g	1 g	$55		Add to Cart
BHB21300349-2	T-220_250 mg	250 mg	$37		Add to Cart
BHB21300349-3	T-220_5 g	5 g	$75		Add to Cart

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