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Home / Biochemicals / Small Molecules

Triacsin C

SKU : BHB21300359

An Acyl CoA Synthase Inhibitor

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Mfr.No.	T-750, T-750_0.2 mg, T-750_1 mg
Description	Triacsin C (#T-750) is a highly pure, natural, and biologically active compound.
Molecular Formula	C11H17N3O.
Background	Triacsin C is a fungal metabolite from Streptomyces aureofaciens1 which almost completely inhibits de novo synthesis of triacylglycerol and phospholipid.2,3 This compound specifically inhibits the activity of long chain acyl-CoA synthetase 1 and 4 (IC50~8uM) but has no effect on the activity of acyl-CoA synthetase 5, in intact cells and in cell lysates. Inhibition of these enzymes causes a decrease in the cellular levels of acyl-CoA precursors for lipid synthesis activity, cell proliferation and lipid transformation.4 Kinetic analysis indicates that inhibition of acyl-CoA synthetase by Triacsin C is not competitive with respect to the two substrates of acyl-CoA synthetase (ATP and coenzyme A), but is competitive with respect to long-chain fatty acids. The N-hydroxytriazene moiety of Triacsin C has been suggested to be essential for the inhibitory activity against acyl-CoA synthetase.2-4Triacsin C arrests the metabolism of arachidonic acid by inhibition of arachidonoyl-CoA synthetase thus interfering in the production of prostaglandins and in the regulation of blood pressure.5
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	>10 nM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	76896-80-5
Molecular Weight	207.3
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Source	Natural
Activity	Triacsin C nearly completely inhibits de novo synthesis of triacylglycerol and phospholipids1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-((E)-((2E,4E,7E)-undeca-2,4,7- trienylidene)amino)nitrous amide.

Purity	>94%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to two weeks at 4°C or six months at -20°C.Protect from light.

Product Manual	SDS

Reference	Yoshida, K. et al. (1982) J. Antibiot. (Tokyo) 35, 151. Omura, S. et al. (1986) J. Antibiot. (Tokyo) 39, 1211. Tomoda, H. et al. (1987) Biochim. Biophys. Acta. 17, 595. Tomoda, H. et al. (1991) J. Biol. Chem. 266, 4214. Hartman, E.J. et al. (1989) Prostaglandins 37, 655. Omura, S. et al. (1986) J. Antibiot. (Tokyo) 39, 1211. Tomoda, H. et al. (1987) Biochim. Biophys. Acta 17, 595.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300359-1	T-750_0.2 mg	0.2 mg	$273		Add to Cart
BHB21300359-2	T-750_1 mg	1 mg	$908		Add to Cart
BHB21300359-3	T-750_0.2 mg	5x0.2 mg	$1079		Add to Cart

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