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Home / Biochemicals / Small Molecules

Tropanyl-3,5-dimethylbenzoate

SKU : BHB21300338

An Antagonist of 5-HT3 Receptors

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Mfr.No.	T-135, T-135_100 mg, T-135_25 mg, T-135_50 mg
Description	Tropanyl-3,5-dimethylbenzoate (#T-135) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H23NO2.
Background	Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid Tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Tropanyl-3,5-dimethylbenzoate is a synthetic, potent and selective antagonist of the 5-HT3 receptor. Tropanyl-3,5-dimethylbenzoate has an effective concentration of 1 nM - 1 uM. Interestingly, in rat mucosa and submucosa preparations Tropanyl causes an increase of 5-HT induced delta/sc (change in short circuit current) and causes a decline of delta/sc in rat intact colon suggesting a double role for 5-HT3 receptors in this tissue2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1 uM.
Reconstitution	50-100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	85181-40-4
Molecular Weight	273.4
Solubility	50-100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3 receptors
Source	Synthetic
Activity	Tropanyl-3,5-dimethylbenzoate is a 5-HT3 receptor antagonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (8-methyl-8-azabicyclo(3.2.1)octan-3-yl) 3,5-dimethylbenzoate.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hannon, J. et al. (2008) Behav. Brain Res. 195, 198. Yang, N. et al. (2008) Eur. J. Pharmacol. 584, 137. Yang, N. et al. (2010) Br. J. Pharmacol. 159, 1623.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300338-1	T-135_100 mg	100 mg	$151		Add to Cart
BHB21300338-2	T-135_25 mg	25 mg	$66		Add to Cart
BHB21300338-3	T-135_50 mg	50 mg	$85		Add to Cart

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