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Home / Biochemicals / Small Molecules

TTA-P2 (S-enantiomer)

SKU : BHB21300347

A Blocker of T-Type CaV Channels

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Alomone Labs

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Mfr.No.	T-210, T-210_1 mg, T-210_10 mg, T-210_5 mg
Description	TTA-P2 (S-enantiomer) (#T-210) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C21H29Cl2FN2O2.
Background	TTA-P2 is a novel, potent and selective T-type CaV channel blocker. In thalamocortical and reticular neurons, it blocks T-type currents with an IC50 of 22 nM without affecting high voltage Ca2+ channels1. In rat DRGs, it blocks T-type currents with an IC50 of 100 nM and stabilizes the channel in the inactive state2.TTA-P2 has the potential of acting as an antinociceptive agent2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.05-10 uM.
Reconstitution	50 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
Cas Number	1072018-68-8
Molecular Weight	431
Solubility	50 mM in DMSO. Centrifuge all product preparations before use (10,000 x g for 1 min).
Target	CaV3 channels
Source	Synthetic
Activity	TTA-P2 blocks T-type currents in DRGs with IC50 of 100 nM and 22 nM in thalamocortical and reticular neurons1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: (S)-3,5-Dichloro-N-((1-((2,2-dimethyltetrahydro-2H-pyran-4-yl)methyl)-4-fluoropiperidin-4-yl)methyl)benzamide.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Dreyfus, F.M. et al. (2010) J. Neurosci. 30, 99. Choe, W. et al. (2011) Mol. Pharmacol. 80, 900. Choe, W. et al. (2011) Mol. Pharmacol. 80, 900. Dreyfus, F.M. et al. (2010) J. Neurosci. 30, 99.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300347-1	T-210_1 mg	1 mg	$202		Add to Cart
BHB21300347-2	T-210_10 mg	10 mg	$1279		Add to Cart
BHB21300347-3	T-210_5 mg	5 mg	$799		Add to Cart

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