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Home / Biochemicals / Small Molecules

U 93631

SKU : BHB21300363

An Antagonist of GABA(A) and 5-HT3A Receptors

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Mfr.No.	U-120, U-120_10 mg, U-120_25 mg, U-120_5 mg, U-120_50 mg
Description	U 93631 (#U-120) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H21N3O2.
Background	U 93631 is a synthetic compound that acts as an antagonist of the gamma-aminobutyric acid type A GABA(A) receptors and of 5-hydroxytryptamine type 3A (5-HT3A) receptors, displaying an IC50 of 50 uM for the serotonin receptor4. The compound accelerates the decay of GABA induced currents through an allosteric manner. The properties of U 93631 are shown to be analogous to those of picrotoxin and both share overlapping binding domains1,2.GABA(A) receptors and 5-HT3 (serotonin-gated) receptor channels are members of the Cys-loop superfamily of ligand-gated ion channels. These receptors are expressed throughout the central and peripheral nervous systems and mediate a variety of important physiological functions. GABA(A) receptors mediate the actions of GABA, a major inhibitory neurotransmitter. 5-HT3 receptors mediate those of serotonin3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-10 uM.
Reconstitution	Soluble in DMSO. Centrifuge before use (10000 x g, 5 min).
Cas Number	152273-12-6
Molecular Weight	299.37
Solubility	Soluble in DMSO. Centrifuge before use (10000 x g, 5 min).
Target	GABA(A), 5-HT3A receptors
Source	Synthetic
Activity	U 93631 is a ligand at the picrotoxin site of GABA(A) receptors, allosterically antagonizing GABA-induced Cl- currents by decreasing single-channel open probability1 and accelerating current decay (Kd = 2 uM)2. It is also an antagonist of 5-HT3A receptors (IC50 = 50 uM)3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: tert-butyl 4,4-dimethyl-5H-imidazo(1,5-a)quinoxaline-3-carboxylate.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Dillon, G.H. et al. (1995) J. Pharmacol. Exp. Ther. 272, 597. Dillon, G.H. et al. (1993) Mol. Pharmacol. 44, 860. Williams, M. et al. (1989) J. Pharmacol. Exp. Ther. 248, 89. Das, P. et al. (2003) Neuropharmacology 44, 431. Dillon, G.H. et al. (1995) J. Pharmacol. Exp. Ther. 272, 597. Dillon, G.H. et al. (1993) Mol. Pharmacol. 44, 860. Das, P. et al. (2003) Neuropharmacology 44, 431.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300363-1	U-120_10 mg	10 mg	$168		Add to Cart
BHB21300363-2	U-120_25 mg	25 mg	$355		Add to Cart
BHB21300363-3	U-120_5 mg	5 mg	$117		Add to Cart
BHB21300363-4	U-120_50 mg	50 mg	$577		Add to Cart

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