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Home / Biochemicals / Small Molecules

U0126

SKU : BHB21300364

A Specific MAPK Pathway Inhibitor

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Alomone Labs

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Mfr.No.	U-400, U-400_1 mg, U-400_5 mg
Description	U0126 (#U-400) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H16N6S2.
Background	U0126 is a chemically synthesized organic compound that was initially recognized as a cellular AP-1 antagonist, and found to be a very selective and highly potent inhibitor of the Mitogen-Activated Protein Kinase (MAPK) cascade by inhibiting its immediate upstream activators, Mitogen-Activated Protein Kinase Kinase 1 and 2 (also known as MEK1 and MEK2, IC50: 70 and 60 nM respectively). U0126 inhibits both active and inactive MEK1,2, unlike PD098059 which only inhibits activation of inactive MEK1,2. Blockade of MEK activation would prevent downstream phosphorylation of a number of factors including p62TCF (Elk-1), an upstream inducer of c-Fos and c-Jun, components of the AP-1 complex.1-4Inhibition of the MEK/ERK pathway by U0126 also prevents all effects of oncogenic H-Ras and K-Ras, inhibits part of the effects triggered by growth factors and blocks the production of inflammatory cytokines and matrix metalloproteinases.5-11
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-100 uM.
Reconstitution	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	109511-58-2
Molecular Weight	380.5
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	MAPK Pathway
Source	Synthetic
Activity	U0126 specifically inhibits the kinase activity of mitogen activated protein kinase kinase (MAPKK, MEK1 and MEK2). It is less toxic than PD 980591,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1,4-Diamino-2,3-dicyano-1,4-bis(2- aminophenylthio)butadiene.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to two weeks at 4°C or six months at -20°C.Protect from light.

Product Manual	SDS

Reference	Favata, M.F. et al. (1998) J. Biol. Chem. 273, 18623. Lockman, K. et al. (2004 ) J. Biol. Chem. 279, 42422. Cirillo, P. et al. (2004) Circulation 109, 2911. Duncia, J.V. et al. (1998) Bioorg Med Chem Lett. 8, 2839. Zhang, J. et al. (2004) Blood 104, 1679. Ninomiya, Y. et al. (2004) Cancer Res. 64, 2759. Sharma, PM. et al. (2005) Mol Endocrinol. 19, 421. Ichiki, T. et al. (2004) Biochem Biophys Res Commun. 323, 402. MacCormick, M. et al. (2005) Biochem J. 387, 155. Fukazawa, H. et al. (2000) Cancer Res. 60, 2104. Favata, M.F. et al. (1998) J. Biol. Chem. 273, 18623. Duncia, J.V. et al. (1998) Bioorg. Med. Chem. Lett. 8, 2839.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300364-1	U-400_1 mg	1 mg	$75		Add to Cart
BHB21300364-2	U-400_5 mg	5 mg	$243		Add to Cart
BHB21300364-3	U-400_1 mg	5x1 mg	$282		Add to Cart

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