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Home / Biochemicals / Small Molecules

UK-78282 hydrochloride

SKU : BHB21300361

A Blocker of KV1.3 and KV1.4 K+ Channels

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Alomone Labs

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Mfr.No.	U-100, U-100_10 mg, U-100_25 mg, U-100_5 mg, U-100_50 mg
Description	UK-78282 hydrochloride (#U-100) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C29H36ClNO2.
Background	UK-78282 hydrochloride is a novel piperidine blocker of the T lymphocyte voltage-gated K+ channel, KV1.3 and KV1.4 with IC50 values of 0.28 and 0.17 uM respectively. UK-78282 suppresses T lymphocyte mitogenesis and leads to membrane depolarization. UK-78282 also blocks KV1.4 expressed in heart and brain. UK-78282 preferentially blocks the C-type inactivated state of the KV1.3 channel. KV1.3 mutants containing hydrophobic residues that might prefer to be buried, transition slowly into the C-type inactivated conformation and are insensitive to block by UK-78282, possibly because of the inability of the drug to bind the channel. UK-78282 hydrochloride serves as an experimental tool to probe the conformational changes in KV1.3 leading to C-type inactivation and to further define the critical physiological role of KV1.3 in T lymphocyte activation1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	200 nM - 200 uM.
Reconstitution	200 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Cas Number	136647-02-4
Molecular Weight	466.1
Solubility	200 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	KV1.3, KV1.4 K+ channels
Source	Synthetic
Activity	UK-78282 hydrochloride blocks KV1.3 and KV1.4 in T lymphocytes1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-(benzhydryloxymethyl)-1-(3-(4-methoxyphenyl)propyl)piperidine;hydrochloride.

Purity	>95%
Form	Lyophilized Powder
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hanson, D.C. et al. (1999) Br. J. Pharmacol. 126, 1707. Hanson, D.C. et al. (1999) Br. J. Pharmacol. 126, 1707.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300361-1	U-100_10 mg	10 mg	$254		Add to Cart
BHB21300361-2	U-100_25 mg	25 mg	$561		Add to Cart
BHB21300361-3	U-100_5 mg	5 mg	$151		Add to Cart
BHB21300361-4	U-100_50 mg	50 mg	$1003		Add to Cart

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