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Home / Biochemicals / Small Molecules

VU590 dihydrochloride

SKU : BHB21300369

A Blocker of Kir1.1 and Kir7.1 K+ Channels

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Alomone Labs

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Mfr.No.	V-130, V-130_10 mg, V-130_25 mg, V-130_5 mg, V-130_50 mg
Description	VU590 dihydrochloride (#V-130) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C24H34Cl2N4O7.
Synonyms	Synthetic
Background	VU590 dihydrochloride is a synthetic blocker of Kir1.1 channel with an IC50 of 294nM for Kir1.1 channel. VU590 also inhibits Kir7.1 channels at micromolar concentrations whilst having no effect on Kir2.1 or Kir4.1 channels. At a voltage of -120mV VU590 inhibits Kir1.1 currents by 95.3±0.5%. Inhibition of the Kir1.1 channel is dose dependent. 10 uM of VU590 cause a slow rate inhibition of Kir1.1 with a time constant of 40.0±0.5 s suggesting that VU590 first has to cross the plasma membrane in order to reach its binding site. Kir1.1 block by VU590 is relieved by hyperpolarizing pulses and increased extracellular K+ concentrations. This is hypothesized to be achieved by increased blocker dissociation into the cytoplasmic compartment when exposed to these conditions. The binding site of VU590 within the Kir1.1 channel is yet to be determined1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-25 uM.
Reconstitution	Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	313505-85-0
Molecular Weight	561.46
Solubility	Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	Kir1.1, Kir7.1 channels
Activity	VU590 inhibits ROMK1 channels in a dose-dependent manner with an IC50 of 294 nM. Inhibits Kir7.1 at micromolar concentrations, whilst having no effect on Kir2.1 or Kir4.11.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 7,13-bis((4-nitrophenyl)methyl)-1,4,10-trioxa-7,13-diazacyclopentadecane dihydrochloride.

Purity	>98% (HPLC)
Form	Lyophilized Powder
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Lewis, L.M. et al. (2009) Mol. Pharmacol. 76, 1094. Lewis, L.M. et al. (2009) Mol. Pharmacol. 76, 1094.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300369-1	V-130_10 mg	10 mg	$117		Add to Cart
BHB21300369-2	V-130_25 mg	25 mg	$263		Add to Cart
BHB21300369-3	V-130_5 mg	5 mg	$66		Add to Cart
BHB21300369-4	V-130_50 mg	50 mg	$476		Add to Cart

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